HPX / Hemopexin抗体

HPX / Hemopexin抗体产品信息

免疫原 :
Recombinant mouse HPX protein ( Catalog#50271-M08H )
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant mouse Hemopexin ( rM Hemopexin ; Catalog#50271-M08H ; NP_059067.2 ; Met 1 - Gln 460 ). Total IgG was purified by Protein A affinity chromatography
HPX / Hemopexin抗体背景综述
Mouse Hemopexin ( HPX ) is a serum glycoprotein responsible for the transport of haem to tissues such as liver, by receptor-mediated endocytosis, in an analogous manner to the iron transport protein transferrin, with recycling of intact haemopexin. Hemopexin binds heme with the highest affinity of any known protein. Its performs functions in scavenging the heme released or lost by the turnover of heme proteins such as hemoglobin, protects the body from the oxidative damage that free heme can cause. In addition, hemopexin releases its bound ligand for internalisation upon interacting with a specific receptor situated on the surface of liver cells, thus implicated in preservation of the body's iron. High hemopexin levels indicate that there has been significant degradation of heme containing compounds and hemopexin is made to scavenge any heme it can, and high hemopexin levels are therefore one of the diagnostic features of a hemolytic anemia. Hemopexin is an acute-phase plasma glycoprotein, produced mainly by the liver and released into plasma, where it binds heme with high affinity. Other sites of hemopexin synthesis are the nervous system, skeletal muscle, retina, and kidney. The only known receptor for the heme-hemopexin complex is the scavenger receptor, LDL receptor-related protein (LRP)1, which is expressed in most cell types, thus indicating multiple sites of heme-hemopexin complex recovery.
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