CDON抗体

CDON抗体产品信息

免疫原 :
Recombinant Human CDON protein (Catalog#11965-H08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
076
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Human CDON (rh CDON; Catalog#11965-H08H; AAI14436.1; Met1-Asp963).
CDON抗体 Background
Cell adhesion molecule-related, down-regulated by oncogenes (CDON or CDO), an Ig superfamily member, is a component of a cell surface receptor that positively regulates skeletal myogenesis. CDO and MyoD are involved in a positive feedback loop that is central to the inverse relationship between cell differentiation and transformation. It is proposed that CDO mediates, at least in part, the effects of cell-cell interactions between muscle precursors that are critical in myogenesis. The Bnip-2/Cdc42 and JLP/p38alpha/beta complexes associate in a Cdo-dependent manner, resulting in Bnip-2/Cdc42-dependent p38alpha/beta activation and stimulation of cell differentiation. The immunoglobulin superfamily members CDON and Brother of CDO (BOC) are components of a cell surface receptor that positively regulates myogenesis in vitro. Expression of Cdo and Boc in myoblast cell lines is downregulated by the ras oncogene, and forced re-expression of either Cdo or Boc can override ras-induced inhibition of myogenic differentiation. CDO and BOC play a role in the inverse relationship between differentiation and transformation of cells in the skeletal muscle lineage. CDON and BOC are the closest mammalian relatives of Drosophila Ihog, and CDO binds Sonic Hedgehog (Hh) with micromolar affinity and positively regulates Hh signaling. all mammalian Hh proteins bind CDO and BOC in the same manner.
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