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文献和实验Identification of MHC Class II Binding Peptides: Microarray and Soluble MHC Class II Molecules
binding peptides. We present here a high content screening for MHC class II (HLA-DR) binding to a peptide library in a chip-format. Binding of soluble MHC class II molecules to individual peptides can be visualized using an anti-DR directed monoclonal
), and then to deliver the peptide-MHC complexes to the plasma membrane in order to stimulate T cells. It is becoming increasingly clear that most of the intracellular compartments that contain MHC class II products in APC simply represent the conventional endosomes
Advances in immunology and immune therapies require knowledge of antigenic peptide sequences that are presented on MHC class II and class I molecules of antigen presenting cells. The most specialized antigen presenting cells are dendritic
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