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- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
CD163 Molecule (CD163) 抗体
CD163 Molecule (CD163) 抗体
抗原
CD163 Molecule (CD163)
别名 DMBT1, CD163, CD163v2, CD163v3, M130, MM130
适用
其他选择 人, 猴
宿主
其他选择 小鼠
克隆类型 (克隆位点)
单克隆 (RM3-1)
标记
其他选择 非结合性
CD163 Molecule (CD163) 抗体应用范围
其他选择 Immunohistochemistry (Frozen Sections) (IHC (fro)), 流式细胞分析技术（FACS）, Western Blotting (WB)
Pubmed 2个引用可参考
规格 0.2 mg
发货至 中国 (更改)
产品细节
免疫原 Human monocytes, particularly after dexamethasone treatment or after 2-5 days in culture
克隆位点 RM3-1
亚型 IgG1
特异性 This antibody is specific for CD163. Clone RM 3/1 recognizes a membrane glycoprotein on monocytes and macrophages which is expressed in intermediate and late inflammatory stages. Does not react with lymphocytes, granulocytes or platelets. Positive staining can be observed in the skin (histiocytes), gut, Kupffer cells, few alveolar macrophages, a major population of macrophages in the placenta, varying degrees of macrophages in inflamed tissues, including tumorous tissue depending on the inflammatory stage. Red pulp, but not white pulp macrophages of the spleen, and cortical macrophages of the thymus are detected. Macrophages in the synovialis of patients with rheumatoid arthritis. In alveolar macrophages and in Kupffer cells a double staining can be observed with clone 25F9 which is not the case in other tissues.
交叉反应 （详细） Species reactivity (tested):Human, Monkey. Negative in Pig, Rabbit and Guinea Pig.
纯化方法 Affinity Chromatography
目标详细情况
别名 CD163
背景 CD163 is a scavenger receptor for the haemoglobin-haptoglobin complex, and is upregulated by glucocorticoids and IL-10. The extracellular portion of the receptor is regularly shed and can be found in the circulation. An important function of CD163 seems to be in the adhesion of monocytes to activated endothelial cells. CD163-positive cells include skin histiocytes, Kupffer cells, spleen macrophages of the red pulp, and some thymus macrophages. The antigen is also found abundantly in human term placenta, and regularly in acute and chronic inflammatory lesions.Synonyms: Hemoglobin scavenger receptor, M130, Macrophage marker, Scavenger receptor cysteine-rich type 1 protein M130
基因ID 9332
CD163 Molecule (CD163) 抗体UniProt Q86VB7
研究领域 Cardiovascular, Atherosclerosis, CD Antigens, Innate Immunity, Surface Receptors of Immune Cells
使用细节
应用备注 Immunohistochemistry on Frozen Sections: 4 μg/mL (1/100). Does not work in routinely processed paraffin sections. Has been described to work in FACS and Western blots. Recommended Positive control: Human placenta.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
贮存及处理
溶解方式 Restore with 0.5 mL distilled water to a concentration of 0.4 mg/mL.
浓度 0.4 mg/mL
缓冲液 Stock solutions contains PBS, pH 7.2, 10 mg/mL BSA as a stabilizer and 0.01 % Thimerosal as a preservative
储存液 Thimerosal (Merthiolate)
注意事项 This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 This product is photosensitive and should be protected from light
储存条件 4 °C
储存方法 Store the antibody undiluted Prior to and after reconstitution at 2-8 °C. DO NOT FREEZE!
CD163 Molecule (CD163) 抗体相关产品如下：xy-12988R DEF6/IBP干扰素调节因子4结合蛋白抗体
xy-12533R DCLREC1CDNA交联修复蛋白1C抗体
xy-12980R phospho-DAP Kinase 2 (Ser318)磷酸化凋亡相关蛋白激酶2抗体
xy-12981R DAPL1凋亡相关蛋白激酶样蛋白1抗体
xy-12576R phospho-DAP Kinase 1 (Ser 308)磷酸化凋亡相关蛋白激酶1抗体
xy-12359R DMP1牙本质基质蛋白1抗体
xy-12332R DYRK2双特异性酪氨酸磷酸化调节激酶DYRK2抗体
xy-7418R DHHC-20锌指结构蛋白酶20抗体
xy-13760R DCL-1C型凝集素受体CLEC13A抗体
xy-2785R DDAH2双甲基精氨酸水解酶2抗体
xy-1467R DOK1D酪氨酸激酶衰减蛋白1抗体
xy-9520R DYRK3双特异性酪氨酸磷酸化调节激酶3抗体
xy-3607R Dystrobrevin alpha肌营养蛋白α抗体
xy-0596R DBH多巴胺β羟化酶抗体
xy-0595R GP340抑癌基因抗体
xy-0678R Dnmt1DNA甲基转移酶1抗体
xy-0497R Dnmt3aDNA甲基转移酶-3α抗体
xy-0301R Dnmt3 BetaDNA甲基转移酶-3β抗体
xy-0421R DR3死亡受体3抗体
xy-0591R DR4/死亡受体4抗体
xy-1561R DTNBP1精神分裂症易感基因抗体
xy-0598R DVL1蓬乱蛋白1抗体
xy-3548R DTNB肌萎缩Dystrobrevin β蛋白抗体
xy-1037R DCP异常凝血酶原/脱-γ-羧基凝血酶原抗体
xy-1026R Desmin结蛋白抗体
xy-0430R DISC1 (CT)DISC1 C端抗体
xy-0428R DISC1 (NT)DISC1 N端抗体
xy-0597R DPPA2多能发育相关基因2抗体
xy-0592R DCC结肠直肠癌缺失基因抗体
xy-0180R DOPA Decarboxylase多巴胺脱羧酶抗体
xy-1163R beta Defensin 1防御素β1/Defensin β1抗体
抗原
CD163 Molecule (CD163)
别名 DMBT1, CD163, CD163v2, CD163v3, M130, MM130
适用
其他选择 人, 猴
宿主
其他选择 小鼠
克隆类型 (克隆位点)
单克隆 (RM3-1)
标记
其他选择 非结合性
CD163 Molecule (CD163) 抗体应用范围
其他选择 Immunohistochemistry (Frozen Sections) (IHC (fro)), 流式细胞分析技术（FACS）, Western Blotting (WB)
Pubmed 2个引用可参考
规格 0.2 mg
发货至 中国 (更改)
产品细节
免疫原 Human monocytes, particularly after dexamethasone treatment or after 2-5 days in culture
克隆位点 RM3-1
亚型 IgG1
特异性 This antibody is specific for CD163. Clone RM 3/1 recognizes a membrane glycoprotein on monocytes and macrophages which is expressed in intermediate and late inflammatory stages. Does not react with lymphocytes, granulocytes or platelets. Positive staining can be observed in the skin (histiocytes), gut, Kupffer cells, few alveolar macrophages, a major population of macrophages in the placenta, varying degrees of macrophages in inflamed tissues, including tumorous tissue depending on the inflammatory stage. Red pulp, but not white pulp macrophages of the spleen, and cortical macrophages of the thymus are detected. Macrophages in the synovialis of patients with rheumatoid arthritis. In alveolar macrophages and in Kupffer cells a double staining can be observed with clone 25F9 which is not the case in other tissues.
交叉反应 （详细） Species reactivity (tested):Human, Monkey. Negative in Pig, Rabbit and Guinea Pig.
纯化方法 Affinity Chromatography
目标详细情况
别名 CD163
背景 CD163 is a scavenger receptor for the haemoglobin-haptoglobin complex, and is upregulated by glucocorticoids and IL-10. The extracellular portion of the receptor is regularly shed and can be found in the circulation. An important function of CD163 seems to be in the adhesion of monocytes to activated endothelial cells. CD163-positive cells include skin histiocytes, Kupffer cells, spleen macrophages of the red pulp, and some thymus macrophages. The antigen is also found abundantly in human term placenta, and regularly in acute and chronic inflammatory lesions.Synonyms: Hemoglobin scavenger receptor, M130, Macrophage marker, Scavenger receptor cysteine-rich type 1 protein M130
基因ID 9332
CD163 Molecule (CD163) 抗体UniProt Q86VB7
研究领域 Cardiovascular, Atherosclerosis, CD Antigens, Innate Immunity, Surface Receptors of Immune Cells
使用细节
应用备注 Immunohistochemistry on Frozen Sections: 4 μg/mL (1/100). Does not work in routinely processed paraffin sections. Has been described to work in FACS and Western blots. Recommended Positive control: Human placenta.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
贮存及处理
溶解方式 Restore with 0.5 mL distilled water to a concentration of 0.4 mg/mL.
浓度 0.4 mg/mL
缓冲液 Stock solutions contains PBS, pH 7.2, 10 mg/mL BSA as a stabilizer and 0.01 % Thimerosal as a preservative
储存液 Thimerosal (Merthiolate)
注意事项 This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 This product is photosensitive and should be protected from light
储存条件 4 °C
储存方法 Store the antibody undiluted Prior to and after reconstitution at 2-8 °C. DO NOT FREEZE!
CD163 Molecule (CD163) 抗体相关产品如下：xy-12988R DEF6/IBP干扰素调节因子4结合蛋白抗体
xy-12533R DCLREC1CDNA交联修复蛋白1C抗体
xy-12980R phospho-DAP Kinase 2 (Ser318)磷酸化凋亡相关蛋白激酶2抗体
xy-12981R DAPL1凋亡相关蛋白激酶样蛋白1抗体
xy-12576R phospho-DAP Kinase 1 (Ser 308)磷酸化凋亡相关蛋白激酶1抗体
xy-12359R DMP1牙本质基质蛋白1抗体
xy-12332R DYRK2双特异性酪氨酸磷酸化调节激酶DYRK2抗体
xy-7418R DHHC-20锌指结构蛋白酶20抗体
xy-13760R DCL-1C型凝集素受体CLEC13A抗体
xy-2785R DDAH2双甲基精氨酸水解酶2抗体
xy-1467R DOK1D酪氨酸激酶衰减蛋白1抗体
xy-9520R DYRK3双特异性酪氨酸磷酸化调节激酶3抗体
xy-3607R Dystrobrevin alpha肌营养蛋白α抗体
xy-0596R DBH多巴胺β羟化酶抗体
xy-0595R GP340抑癌基因抗体
xy-0678R Dnmt1DNA甲基转移酶1抗体
xy-0497R Dnmt3aDNA甲基转移酶-3α抗体
xy-0301R Dnmt3 BetaDNA甲基转移酶-3β抗体
xy-0421R DR3死亡受体3抗体
xy-0591R DR4/死亡受体4抗体
xy-1561R DTNBP1精神分裂症易感基因抗体
xy-0598R DVL1蓬乱蛋白1抗体
xy-3548R DTNB肌萎缩Dystrobrevin β蛋白抗体
xy-1037R DCP异常凝血酶原/脱-γ-羧基凝血酶原抗体
xy-1026R Desmin结蛋白抗体
xy-0430R DISC1 (CT)DISC1 C端抗体
xy-0428R DISC1 (NT)DISC1 N端抗体
xy-0597R DPPA2多能发育相关基因2抗体
xy-0592R DCC结肠直肠癌缺失基因抗体
xy-0180R DOPA Decarboxylase多巴胺脱羧酶抗体
xy-1163R beta Defensin 1防御素β1/Defensin β1抗体
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文献和实验相关实验
人可溶性CD163分子(sCD163)ELISA试剂盒 说明书
人可溶性CD163 分子 ( sCD163 )ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和其它生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗人 sCD163 单抗包被于酶标板上，标准品和样品中的 sCD163与单抗结合，加入生物素化的抗人 sCD163 ，形成免疫复合物连接在板上，辣根过氧化物酶标记的 Streptavidin 与生物素结合，加入底物工作液显蓝色，最后
神经细胞粘着分子(neural cell adhesion molecule,N-CAM)
N-CAM是膜糖蛋白,至少以三种形式存在,但都是由同一基因编码。其中两种是跨膜蛋白,第三种共价结合在细胞质膜的外表面。无论是何种存在方式,N-CAM分子都有一部分伸出到细胞外表面。三种N-CAM在细胞外的结构都一样,都含有与细胞粘着相关的结合位点。 将分离纯化的N-CAM加入到人工磷脂脂质体中, 这种人工脂质体能够相互粘着,但是加入了相应的抗体就不会发生粘着, 不加N-CAM的人工脂质体也不会发生粘着。由此可以推测:细胞粘着是由细胞质膜中的蛋白分子介导的,N
感染新冠后，为何会导致长期嗅觉丧失？杜克大学的科学家找到了关键原因
上皮组织中的免疫浸润。 图片来源：Science Translational Medicine 而对巨噬细胞簇的分析则显示，CD163 标记的抗炎 M2 巨噬细胞数量存在明显差异。这种 M2 巨噬细胞的减少是值得关注的，因为 M2 巨噬细胞可以通过几种机制促进组织修复，特别是考虑到这里观察到的 M2 巨噬细胞产生胰岛素样生长因子 1（IGF1），这是一种已知的嗅觉感觉神经元生长因子。因此，PASC 组嗅觉上皮中 M2 巨噬细胞的相对减少也可能作为促炎信号，并可抑制嗅觉感觉神经元的修复。 图片
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CD163 Molecule (CD163) 抗体
询价
