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- 中国/美国/德国
- xy10005-MM11
- 2025年07月10日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
CD112 / Nectin-2 / PVRL2抗体
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
Clone ID : 11
抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD112 / Nectin-2 / PVRL2 (rh CD112 / Nectin-2 / PVRL2; Catalog#10005-H08H; Met 1-Leu 360; NP_002847.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
CD112 / Nectin-2 / PVRL2抗体 Background
CD112, also known as poliovirus receptor related 2 (PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily, and structurally comprises two Ig-like C2-type domains and one Ig-like V-type domain in the extracellular region. As a homophilic adhesion molecule, CD112 is widely expressed in human tissues including hematopoietic cells and mediates intercellular junctions of adjacent cells. This protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.
CD112 / Nectin-2 / PVRL2抗体相关产品如下：xy-6618R PAPPA妊娠相关血浆蛋白A抗体
xy-6619R PPT1棕榈酰蛋白硫酯酶1抗体
xy-11995R Phosphoserine/threonine/tyrosine磷酸化丝氨酸/苏氨酸/酪氨酸抗体
xy-4273R PIH1D1核仁同源蛋白17抗体
xy-6203R p53 activated protein 2p53激活蛋白2抗体
xy-6087R PSMD6蛋白酶调解因子10抗体
xy-9169R RNF3环指蛋白3抗体
xy-3962R PDK2丙酮酸脱氢酶激酶亚型2抗体
xy-6092R RHOBTB1Rho相关结构域BTB蛋白质1抗体
xy-2311M Classical swine fever virus, CSFV猪瘟病毒抗体
xy-2283R EMC1腺样癌特异性相关抗原EMC1抗体
xy-3966R PPM2C蛋白磷酸酶2C抗体
xy-9393R CAF1p55染色质组装因子1P55抗体
xy-8458R PTRFRNA聚合酶1和转录释放因子抗体
xy-8866R PISD磷脂酰丝氨酸脱羧酶PISD抗体
xy-3742R PNPLA1含patatin样磷脂酶1抗体
xy-3698R PML早幼粒细胞白血病蛋白抗体
xy-2265R Peptide YY/PYY酪酪肽抗体
xy-9289R PACRG麻疯病和帕金森氏病共同调节蛋白抗体
xy-9290R RNF131环指蛋白131抗体
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xy-3809R thymidine phosphorylase胸苷磷酸化酶抗体
xy-3817R Piwil2piwi样2蛋白抗体
xy-3815R presenilin 2早老素蛋白-2抗体
xy-8176R PHF8组蛋白赖氨酸去甲基化酶PHF8抗体
xy-9363R TRAP2肿瘤坏死因子受体相关蛋白2抗体
xy-9366R PSMD7蛋白酶调解因子7抗体
xy-2215R phosphos-PCNA (Tyr211)磷酸化增殖细胞核抗原抗体
xy-3027R phospho-AMPK beta 1 (Ser182)磷酸化腺苷单磷酸活化蛋白激酶β1抗体
xy-4033R PDHB丙酮酸脱氢酶E1β亚单位抗体
xy-4032R PHKB磷酸化酶β抗体
xy-4030R Pancreatic Amylase胰淀粉酶抗体
xy-4034R PDHA1丙酮酸脱氢酶α1抗体
xy-4036R phospho-PDHA1(Ser293)磷酸化丙酮酸脱氢酶α1抗体
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文献和实验人转录因子E2F1 ( E2F1 )ELISA 试剂盒 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗人 E2F1 单抗包被于酶标板上，标准品和样品中的 E2F1与单抗结合，加入生物素化的抗人 E2F1 ，形成免疫复合物连接在板上，辣根过氧化物酶标记的 Streptavidin 与生物素结合，加入底物工作液显蓝色，最后加终止液硫酸，在 450nm 处测 OD 值，E2F1 浓度与 OD 值成正比
x2值表 n＇ P 0.995 0.990 0.975 0.950
X性联无丙种球蛋白血症(X-linked agammagl，bulinemia，XLA)是临床上首次确定的体液免疫缺陷病，由Brutor于1952年报道，故又称Bruton病。XLA作为常见的原发性免疫缺陷病之一，特点为血清中各类免疫球蛋白缺乏，或只能测得微量的抗体。外周血和淋巴组织中B细胞减少或完全缺乏，淋巴结中无生发中心和浆细胞。本病起病早，在出生数月后当患儿体内的母源性抗体水平下降时开始发病。临床表现为反复化脓性感染，患者细胞免疫功能不受影响(部分患者有T细胞数量减少)，主要缺陷
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