KIM-1 / HAVCR1抗体

KIM-1 / HAVCR1抗体产品信息免疫原 : Recombinant canine HAVCR1 protein ( Catalog#70001-D07H )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant canine HAVCR1 extracellular domain ( TIMD-1 / HAVCR1 ; Catalog#70001-D07H ; XP_854888.1 ; Tyr 21 - Ser 160 ). Total IgG was purified by Protein A affinity chromatography.
KIM-1 / HAVCR1抗体背景综述
Canine hepatitis A virus cellular receptor 1 ( HAVCR1), also known as T cell immunoglobulin and mucin domain-containing protein 1 (TIMD1) and T cell membrane protein 1 (TIM1), is a member of the TIM family, an immunologically important group of receptors that is conserved in vertebrates. HAVCR1 is widely expressed with highest levels in kidney and testis. It has been shown that HAVCR1 is expressed by stimulated T-cells during primary antigen stimulation and associates with immunomodulatory properties. HAVCR1 is a type I integral membrane glycoprotein, and in the ECD contains one V-type I g-like domain extended above the cell surface by a mucin-like domain characterized by a variable number of threonine, serine, and proline (TSP) hexameric repeats. HAVCR1 plays a critical role in T-helper cell development and the regulation of asthma and allergic diseases. In addition to HAV, another identified ligand for HAVCR1is TIMD4.
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