TNFRSF4 / CD134抗体

TNFRSF4 ( TNF receptor superfamily member 4 ), also well known as OX40, CD134, TXGP1L, is a T-cell activation antigen structurally belonging to a lymphocyte-specific subgroup of the nerve growth factor and tumor necrosis factor receptor superfamily, which also includes the T-cell antigen CD27, the B-cell antigen CD40, FAS antigen, and the T-cell activation antigen 4-1BB. The human OX40 protein is expressed only on activated CD4(+) T-blasts, and its ligand has been identified as gp34. Interactions between OX40 and its ligand in vivo are necessary for the differentiation of activated B-cells into highly immunoglobulin-producing cells, however not involved in other pathways of antigen-driven differentiation of B-cells such as development of memory cells in the germinal centers. In addition, The OX40 and gp34 system directly mediate adhesion of activated T-cells to vascular endothelial cells, and contributes to growth stimulation of the virus-infected T-cells as well.
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