Mouse CD86 / B7-2抗体

Mouse CD86 / B7-2抗体产品信息免疫原 : Recombinant mouse CD86 protein ( Catalog#50068-M08H )

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 003
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Mouse CD86 extracellular domain ( rM CD86 ; Catalog#50068-M08H ; NP_062261.3 ; Met 1 - Glu 245 ).
Mouse CD86 / B7-2抗体背景综述
Mouse CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte -associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. CD28 has two ligands expressed largely on professional APC, named B7-1 (CD80) and B7-2 (CD86). They are both type I transmembrane proteins with a membrane distal IgV and a membrane proximal Ig constant (IgC) domain and share 25% sequence identity. Although interacting with the same receptors, B7-1 and B7-2 show several distinct features. Binding of B7-2 with CD28 induces the activation of T cell, whereas CTLA-4 acts as a negative regulator and diminishes the immune responses. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. Recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.
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