EphB6 / EPHB6抗体

EphB6 / EPHB6抗体产品信息免疫原 : Recombinant human EphB6 protein ( Catalog#10197-H08H )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human EphB6 ( rh EphB6 ; Catalog#10197-H08H ; NP_004436.1 ; Met 1 - Ser 579 ). Total IgG was purified by Protein A affinity chromatography
EphB6 / EPHB6抗体背景综述
Ephrins are divided into the ephrin-A (EFNA) class and the ephrin-B (EFNB) class based on their structures and sequence relationships. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family, and EphB6 binding to ephrin-B ligands is a unique member in that its kinase domain contains several alterations in conserved amino acids and is catalytically inactive. It is indicated that activated by an Src family kinase, EphB6 can act as both positive and negative regulators in the process of cell adhesion and migration,The large family of Ephrin receptors and their ligands , the ephrins , mediate numerous developmental processes, particularly the establishment of regional pattern in the nervous system. Furthermore, the Eph receptors have been suggested to play important roles in tumor formation, prognosis, and possible gene-therapeutic approaches, and the reduction of EphB6 gene expression is associated with the progression of metastatic diseases.
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