CD66c / CEACAM60抗体

CD66c / CEACAM60抗体产品信息免疫原 : Recombinant human CD66c protein (Catalog#10823-H08H)

Antibody Type : Biotin conjugated Rabbit Polyclonal Antibody ( Antibody Purification Platform )


抗体宿主 : Rabbit IgG

缓冲液 : 0.1 M Sodium phosphate , 0.15M NaCl, pH 7.2, 3% BSA

制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human CEACAM6 / CD66c ( rh CEACAM6; Catalog#10823-H08H; NP_002474.3; Met 1-Gly 320 ). CEACAM6 specific IgG was purified by human CEACAM6 affinity chromatography.
CD66c / CEACAM60抗体背景综述
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. Human CEACAMs include type I transmembrane proteins (CEACAM-1, -3, and -4) and GPI-linked molecules (CEACAM- 5 through -8). There is no human CEACAM-2. Human CEACAM6 is a GPI-linked membrane protein consisting of a signal sequence, an extracellular domain (ECD) containing one N-terminal V-type I g-like domain and two C2-type I g-like domains, and a hydrophobic C-terminal propeptide. The GPI membrane anchor is attached at the C-terminus following cleavage of the propeptide. CEACAM-6 is expressed by granulocytes and their progenitors. It is also expressed by epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas, as well as hyperplastic polyps. Resistance to adhesion-related apoptosis in tumor cells is conferred in the condition of CEACAM6 overexpression.
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