CHI3L1 / YKL40抗体

CHI3L1 / YKL40抗体产品信息免疫原 : Recombinant Human CHI3L1 / YKL40 protein (Catalog#11227-H08H)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human CHI3L1 / YKL40 (rh CHI3L1 / YKL40; Catalog#11227-H08H; NP_001267.2; Met 1-Thr 383). Total IgG was purified by Protein A affinity chromatography.
CHI3L1 / YKL40抗体 Background
Chitinase-3-like protein 1, also known as Cartilage glycoprotein 39, and CHI3L1, is a member of the glycosyl hydrolase 18 family. The principal sources of CHI3L1 are activated macrophages and chondrocytes, neutrophils, and some tissue and tumor cells. CHI3L1 is a secreted glycoprotein that is upregulated in a number of human cancers and in non-neoplastic disease states characterized by chronic inflammation and tissue remodeling. Increased serum levels of CHI3L1 parallel disease severity, poorer prognosis, and shorter survival in many human neoplasias, including cancers of the breast, colon, prostate, ovaries, brain, thyroid, lung, and liver. Increased serum CHI3L1 also correlates with disease severity in rheumatoid arthritis, osteoarthritis, liver fibrosis, inflammatory bowel disease, and bacterial septicemia. CHI3L1 can act as a fibroblast mitogen and can activate several signaling pathways. Elevated levels of CHI3L1 are associated with disorders exhibiting increased connective tissue turnover, such as rheumatoid arthritis, osteoarthritis, scleroderma, and cirrhosis of the liver. The ability of CHI3L1 to bind both proteins and carbohydrates allows potential interactions with a variety of cell-surface and extracellular-matrix proteins, proteoglycans, and polysaccharides, and thus CHI3L1 can interface between proteomics and glycomics. CHI3L1 may play an important role in the capacity of cells to respond to and cope with changes in their environment.
CHI3L1 / YKL40抗体相关产品如下：xy-2672R Cathepsin C/DPP1组织蛋白酶C抗体
xy-0082R Caspase 4半胱胺酸蛋白酶蛋白-4抗体
xy-0087R caspase-3 p12 subunit活化半胱胺酸蛋白酶蛋白3抗体
xy-15276R C7ORF617号染色体开放阅读框61抗体
xy-2183R Claudin 11少突胶质细胞跨膜蛋白抗体
xy-2211R CD80刺激分子B7-1蛋白抗体
xy-2673R C5b-9末端补体复合物抗体
xy-15296R C8orf558号染色体开放阅读框55抗体
xy-15186R C4a+C4b补体C4a+C4b蛋白抗体
xy-2779R CD44v7CD44V7抗体
xy-2780R CD44v10CD44V10抗体
xy-2783R CD44v4CD44V4抗体
xy-2790R Claudin 4紧密连接蛋白4抗体
xy-15221R C6orf1406号染色体开放阅读框140抗体
xy-2776R CACH2L型钙通道蛋白抗体
xy-2781R CACNA1G电压依赖性钙通道Cav3.1抗体
xy-2788R Claudin 3紧密连接蛋白3抗体
xy-3172R phospho-c-Jun (Ser73)磷酸化原癌基因c-Jun抗体
xy-3173R phospho-c-Jun(Ser243)磷酸化原癌基因c-Jun抗体
xy-15079R C1orf861号染色体开放阅读框86抗体
xy-15298R C8ORF598号染色体开放阅读框59抗体
xy-13816R phospho-C5R1 (Ser338)磷酸化补体成分5受体1抗体
xy-13817R Complement component C6补体C6抗体
xy-13818R CEACAM7癌胚抗原相关细胞粘附分子7抗体
xy-13819R Phospho-CEBP beta (Thr188)磷酸化转录调节因子CEBP β抗体
xy-13820R Phospho-CEBP beta (Thr188 + Thr235)磷酸化转录调节因子CEBP β抗体
xy-13821R CEBP Delta转录调节因子C/EBPδ抗体
xy-13822R CEBPE转录调节因子C/EBPε抗体
xy-13823R phospho-CEBPE (Thr74)磷酸化转录调节因子C/EBPε抗体
xy-13826R CEECAM1脑血管内皮细胞粘附分子1抗体
xy-13804R C1QL4补体C1QL4链多肽抗体
xy-13781R C19orf219号染色体开放阅读框2抗体
xy-13807R CCDC62卷曲螺旋结构域蛋白62抗体
xy-13808R CCDC64卷曲螺旋结构域蛋白64抗体
xy-13811R CCDC72卷曲螺旋结构域蛋白72抗体
xy-13812R CCDC73卷曲螺旋结构域蛋白73抗体
xy-13813R CCDC74B卷曲螺旋结构域蛋白74B抗体
xy-13782R C19orf2519号染色体开放阅读框25抗体
xy-13783R C19orf4219号染色体开放阅读框42抗体
xy-13784R C19orf4419号染色体开放阅读框44抗体
xy-13785R C19orf4819号染色体开放阅读框48抗体
xy-13786R C19orf5019号染色体开放阅读框50抗体
xy-13787R C19orf5119号染色体开放阅读框51抗体
xy-13788R C19orf5219号染色体开放阅读框52抗体