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常温，避光
- 克隆性：
单克隆
- 抗体名：
TCN2抗体
TCN2抗体产品信息免疫原 : Recombinant Mouse TCN2 protein (Catalog#50693-M08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Mouse TCN2 (rM TCN2; Catalog#50693-M08H; O88968; Met 1-Trp 430). Total IgG was purified by Protein A affinity chromatography.
TCN2抗体 Background
Transcobalamin II, also known as TCN2 and TC II, is a plasma protein that binds cobalamin (Cbl; vitamin B12) as it is absorbed in the terminal ileum and distributes to tissues. The circulating transcobalamin II-cobalamin complex binds to receptors on the plasma membrane of tissue cells and is then internalized by receptor-mediated endocytosis. Transcobalamin II is a non-glycolated secretory protein of molecular mass 43 kDa. Its plasma membrane receptor (TC II-R) is a heavily glycosylated protein with a monomeric molecular mass of 62 kDa. Human TCN2 gene is composed of nine exons and eight introns spanning approximately 20 kb with multiple potential transcription start sites. A number of genetic abnormalities are characterized either by a failure to express TCN2 or by synthesis of an abnormal protein. The TCN2 deficiency results in cellular cobalamin deficiency, an early onset of megaloblastic anaemia, and neurological abnormalities.
TCN2抗体相关产品如下：xy-0928xy phospho-HP1/heterochromatin protein 1 (pTyr24)(fruit fly)异染色质蛋白1(磷酸化多肽)
xy-0930xy phospho-heterochromatin protein 1 (pTyr41)peptide异染色质蛋白1（磷酸化多肽）
xy-0991xy HPV18 E6人类乳头状瘤病毒18E6
xy-0992xy HPV16-E7/E7 protein(Human papillomavirus type 16)人类乳头状瘤病毒16抗原
xy-1808xy Hpt/HP(haptoglobin)结合珠蛋白/触珠蛋白抗原
xy-1071xy H-ras/Ras/Ras p21 peptide原癌基因H-ras抗原
xy-1409xy HSTF2/HSF2 peptide热休克转录因子2抗原
xy-2145xy Hrasls3/HREV107(HRAS like suppressor 3)HRAS样抑制因子3抗原
xy-1538xy HSP47(Heat shock protein-47)热休克蛋白-47抗原
xy-0889xy HSP-90 Alpha(Heat Shock Protein 90 Alpha )热休克蛋白90α抗体
xy-1387xy HSP-105 (heat sock protein-105)热休克蛋白HSP105抗原
xy-1271xy HtrA2/Omi peptide丝氨酸蛋白酶/线粒体丝氨酸蛋白酶多肽抗原
xy-1363xy Iba-1(Ionized calcium bindingadaptor molecule-1)离子钙接头蛋白抗原
xy-0898xy IFABP(Intestinal Fatty acid binding protein)小肠型脂肪酸结合蛋白抗原
xy-1031xy IFITM1 (interferon induced transmembrane protein 1)干扰素诱导跨膜蛋白1抗原
xy-1578xy human IFN- Alpha (Interferon Alpha )干扰素-α抗原（人）
xy-1463xy IFNGR1/CD119 peptide干扰素-gamma受体1抗原
xy-1108xy IGFBP-2 (Insulin-like Growth Factor Binding Protein 2)胰岛素样生长因子结合蛋白-2（多肽）
xy-1434xy IGFBP-3 (Insulin-like Growth Factor Binding Protein 3)C-term胰岛素样生长因子结合蛋白-3抗原
xy-1312xy IGF-IIBP3(Insulin like growth factor 2 mRNA binding protein 3)胰岛素样生长因子2 mRNA 结合蛋白3抗原
xy-1156xy IKB Beta (Inhibitor of KB)KB抑制蛋白β(多肽)
xy-1287xy IKB Alpha (Inhibitor of KB Alpha)KB抑制蛋白α抗原
xy-0767xy IL-12(Interleukin-12)白介素12抗原（白细胞介素-12）
xy-1789xy IL-12(Interleukin-12)human peptide白介素12抗原(人)
xy-2604xy IL-12R Beta2/IL12RB2 peptide白细胞介素-12受体β2抗原
xy-0560xy IL-13(Interleukin-13)白介素13抗原
xy-1771xy IL-14/Taxilin alpha白介素14抗原
xy-1829xy IL-15(Interleukin-15)白细胞介素-15抗原
xy-1830xy IL-16(Interleukin-16)白介素16抗原
xy-0768xy IL-16/LCF(interleukin-16)(Lymphocyte Chemotactic Factor)白细胞介素-16抗原
xy-0529xy IL-18/IGIF(Interleukin-18)白细胞介素-18/干扰素γ诱导因子
xy-1460xy IL-23R(Interleukin-23 receptor)白介素-23受体抗原
xy-0555xy IL-1 Alpha (Interleukin-1 Alpha )白介素1α抗原
xy-1191xy IL-2 (Interleukin-2)Mouse、Ret白介素2抗原（大、小鼠）
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Mouse TCN2 (rM TCN2; Catalog#50693-M08H; O88968; Met 1-Trp 430). Total IgG was purified by Protein A affinity chromatography.
TCN2抗体 Background
Transcobalamin II, also known as TCN2 and TC II, is a plasma protein that binds cobalamin (Cbl; vitamin B12) as it is absorbed in the terminal ileum and distributes to tissues. The circulating transcobalamin II-cobalamin complex binds to receptors on the plasma membrane of tissue cells and is then internalized by receptor-mediated endocytosis. Transcobalamin II is a non-glycolated secretory protein of molecular mass 43 kDa. Its plasma membrane receptor (TC II-R) is a heavily glycosylated protein with a monomeric molecular mass of 62 kDa. Human TCN2 gene is composed of nine exons and eight introns spanning approximately 20 kb with multiple potential transcription start sites. A number of genetic abnormalities are characterized either by a failure to express TCN2 or by synthesis of an abnormal protein. The TCN2 deficiency results in cellular cobalamin deficiency, an early onset of megaloblastic anaemia, and neurological abnormalities.
TCN2抗体相关产品如下：xy-0928xy phospho-HP1/heterochromatin protein 1 (pTyr24)(fruit fly)异染色质蛋白1(磷酸化多肽)
xy-0930xy phospho-heterochromatin protein 1 (pTyr41)peptide异染色质蛋白1（磷酸化多肽）
xy-0991xy HPV18 E6人类乳头状瘤病毒18E6
xy-0992xy HPV16-E7/E7 protein(Human papillomavirus type 16)人类乳头状瘤病毒16抗原
xy-1808xy Hpt/HP(haptoglobin)结合珠蛋白/触珠蛋白抗原
xy-1071xy H-ras/Ras/Ras p21 peptide原癌基因H-ras抗原
xy-1409xy HSTF2/HSF2 peptide热休克转录因子2抗原
xy-2145xy Hrasls3/HREV107(HRAS like suppressor 3)HRAS样抑制因子3抗原
xy-1538xy HSP47(Heat shock protein-47)热休克蛋白-47抗原
xy-0889xy HSP-90 Alpha(Heat Shock Protein 90 Alpha )热休克蛋白90α抗体
xy-1387xy HSP-105 (heat sock protein-105)热休克蛋白HSP105抗原
xy-1271xy HtrA2/Omi peptide丝氨酸蛋白酶/线粒体丝氨酸蛋白酶多肽抗原
xy-1363xy Iba-1(Ionized calcium bindingadaptor molecule-1)离子钙接头蛋白抗原
xy-0898xy IFABP(Intestinal Fatty acid binding protein)小肠型脂肪酸结合蛋白抗原
xy-1031xy IFITM1 (interferon induced transmembrane protein 1)干扰素诱导跨膜蛋白1抗原
xy-1578xy human IFN- Alpha (Interferon Alpha )干扰素-α抗原（人）
xy-1463xy IFNGR1/CD119 peptide干扰素-gamma受体1抗原
xy-1108xy IGFBP-2 (Insulin-like Growth Factor Binding Protein 2)胰岛素样生长因子结合蛋白-2（多肽）
xy-1434xy IGFBP-3 (Insulin-like Growth Factor Binding Protein 3)C-term胰岛素样生长因子结合蛋白-3抗原
xy-1312xy IGF-IIBP3(Insulin like growth factor 2 mRNA binding protein 3)胰岛素样生长因子2 mRNA 结合蛋白3抗原
xy-1156xy IKB Beta (Inhibitor of KB)KB抑制蛋白β(多肽)
xy-1287xy IKB Alpha (Inhibitor of KB Alpha)KB抑制蛋白α抗原
xy-0767xy IL-12(Interleukin-12)白介素12抗原（白细胞介素-12）
xy-1789xy IL-12(Interleukin-12)human peptide白介素12抗原(人)
xy-2604xy IL-12R Beta2/IL12RB2 peptide白细胞介素-12受体β2抗原
xy-0560xy IL-13(Interleukin-13)白介素13抗原
xy-1771xy IL-14/Taxilin alpha白介素14抗原
xy-1829xy IL-15(Interleukin-15)白细胞介素-15抗原
xy-1830xy IL-16(Interleukin-16)白介素16抗原
xy-0768xy IL-16/LCF(interleukin-16)(Lymphocyte Chemotactic Factor)白细胞介素-16抗原
xy-0529xy IL-18/IGIF(Interleukin-18)白细胞介素-18/干扰素γ诱导因子
xy-1460xy IL-23R(Interleukin-23 receptor)白介素-23受体抗原
xy-0555xy IL-1 Alpha (Interleukin-1 Alpha )白介素1α抗原
xy-1191xy IL-2 (Interleukin-2)Mouse、Ret白介素2抗原（大、小鼠）
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文献和实验相关实验
抗体的结构决定了其对应的功能，同一抗体的V区和C区的氨基酸组成和顺序不同，决定了其功能上的差异。V区和C区的组成和结构，决定了抗体的生物学功能。 图1：抗体的主要功能（图片来源：Abbas et al: Cellular and Molecular Immunology, 7e.) 1、特异性识别功能 抗体可以通过其结构上的可变区域与抗原结合，同时，具有极高的特异性。这种特异性识别功能可以使抗体识别和结合到感染的病原体，肿瘤细胞等不同种类的分子，帮助免疫系统识别并定位到这些分子，进而启动
在生命科学和医学基础研究中，或多或少都需要用到抗体。抗体的应用场景不同、标记物众多，且针对同一标记物市场上往往有多个抗体可供选择，那么，我们如何从成百万上千万种抗体中，挑选出我们想要的那支呢？ 在我们6月份的关于抗体的调研活动中，我们发现，大家更多的是去参考文献或专利中的材料和方法部分，这无疑很大程度上保证了抗体的有效性。其次有45%和34%的受访者会用到百度和谷歌，然而这两个搜索引擎覆盖面颇广，经常会出现抗体无关的搜索结果，而专业用于查找抗体的网站，大家却知之甚少。 因此，本次文章中
第一代抗体—— 血清多克隆抗体（PcAb） 20世纪初期发现血清抗体和细菌毒素的作用，可用于多种疾病的治疗。多克隆抗体生产过程遇到免疫动物制备的血清抗体具有免疫原性和非均质性的特点，给抗体的研究和应用造成困难，但是由于血清多克隆抗体识别抗原的广谱性，以及识别不同表位的各种抗体或识别同种抗原表位的不同克隆的抗体可协同作用，因而能高效地识别抗原和阻断抗原对机体的危害，所以血清抗体至今仍为诊治疾病和生命科学研究重要制剂。 第二代抗体——单克隆抗体（McAb） 将经绵阳红细胞免疫后的小鼠
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TCN2抗体
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