CD23 / FCER2抗体

CD23 / FCER2抗体产品信息免疫原 : Recombinant Mouse CD23 / FCER2 protein (Catalog#50695-M07H)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Mouse CD23 / FCER2 (rM CD23 / FCER2; Catalog#50695-M07H; P20693-1; Glu 51-Pro 331). CD23 / FCER2 specific IgG was purified by Mouse CD23 / FCER2 affinity chromatography.
CD23 / FCER2抗体 Background
Low affinity immunoglobulin epsilon Fc receptor, also known as BLAST-2, C-type lectin domain family 4 member J, Fc-epsilon-RII, Immunoglobulin E-binding factor, Lymphocyte IgE receptor, CD23 and FCER2, is a secreted and single-pass type II membrane protein which is also exists as a soluble excreted form. There are two forms of CD23: CD23a and CD23b. CD23a is present on follicular B cells, whereas CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils, and macrophages. Unlike many of the antibody receptors, CD23 / FCER2 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets. In flow cytometry, CD23 / FCER2 is helpful in the differentiation of chronic lymphocytic leukemia (CD23-positive) from mantle cell leukemia (CD23-negative). CD23 / FCER2 can also be demonstrated in germinal centre B-cells using immunohistochemistry, but it is not present in the resting cells of the surrounding mantle zone. CD23 / FCER2 has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
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