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        CD23分子

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        2097
        CD23 分子
         
        CD23
        常用单克隆抗体或代号: B6,MHM6,Leu20;(Fce RⅡ)
        主要表达细胞: Bm,Ba,Ma,Eo,DC,Pt [B]
        分子质量(kDa)和结构: gp45(C- lectin SF)
        功    能: 参与IgE生成的调节,调节B细胞分化、粘附
         
        CD23
        Aka low affinity IgE receptor
        Regulates IgE synthesis by negative feedback
        Triggers monokine release (TNF, IL-1, IL-6, GM-CSF) by monocytes
        After physiologic germinal cell development, the follicular dendritic cell meshwork expands and follicular dendritic cells in the light zone of the germinal center become CD23 positive
        CD23 also acts as B cell growth factor, promoting differentiation into plasma cells
        Both CD21 and CD23 are dendritic cell markers
        Positive staining (normal): Activated mature B cells expressing IgM or IgD, monocytes/macrophages, T cell subsets, platelets, eosinophils, Langerhans cells, follicular dendritic cells
        Positive staining (disease): B-cell CLL/SLL
        Negative staining: other B cells; mantle cell lymphoma

         
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