CD23分子
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CD23 分子
CD23
常用单克隆抗体或代号： B6,MHM6,Leu20;(Fce RⅡ)
主要表达细胞： Bm,Ba,Ma,Eo,DC,Pt [B]
分子质量(kDa)和结构： gp45(C- lectin SF)
功 能： 参与IgE生成的调节,调节B细胞分化、粘附
CD23
Aka low affinity IgE receptor
Regulates IgE synthesis by negative feedback
Triggers monokine release (TNF, IL-1, IL-6, GM-CSF) by monocytes
After physiologic germinal cell development, the follicular dendritic cell meshwork expands and follicular dendritic cells in the light zone of the germinal center become CD23 positive
CD23 also acts as B cell growth factor, promoting differentiation into plasma cells
Both CD21 and CD23 are dendritic cell markers
Positive staining (normal): Activated mature B cells expressing IgM or IgD, monocytes/macrophages, T cell subsets, platelets, eosinophils, Langerhans cells, follicular dendritic cells
Positive staining (disease): B-cell CLL/SLL
Negative staining: other B cells; mantle cell lymphoma
