ULBP2 / N2DL-2抗体

ULBP2 / N2DL-2抗体产品信息免疫原 : Recombinant Human ULBP2 / N2DL-2 protein (Catalog#12143-H08H)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human ULBP2 / N2DL-2 (rh ULBP2 / N2DL-2; Catalog#12143-H08H; Q9BZM5; Met 1-Ser 217). ULBP2 / N2DL-2 specific IgG was purified by Human ULBP2 / N2DL-2 affinity chromatography.
ULBP2 / N2DL-2抗体 Background
NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein which belongs to theMHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway.
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