Pepsinogen C / PGC抗体

Pepsinogen C / PGC抗体产品信息免疫原 : Recombinant Human Pepsinogen C / PGC protein (Catalog#12072-H08H)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human Pepsinogen C / PGC (rh Pepsinogen C / PGC; Catalog#12072-H08H; NP_002621.1; Met 1-Ala 388). Total IgG was purified by Protein A affinity chromatography.
Pepsinogen C / PGC抗体 Background
Gastricsin, also known as Pepsinogen C and PGC, is a secreted which belongs to thepeptidase A1 family. PGC / Gastricsin hydrolyzes a variety of proteins. PGC / Gastricsin is more restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. It has high activity on hemoglobin. PGC / Gastricsin is an aspartic proteinase that belongs to the peptidase family A1. It is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. It is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Serum levels of this PGC / Gastricsin are used as a biomarker for certain gastric diseases includingHelicobacter pylorirelated gastritis.
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