端粒酶抗体

端粒酶抗体产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

端粒酶抗体产品说明

端粒酶是一种依赖RNA的DNA聚合酶,催化合成端粒体的DNA重复序列,并引导端粒添加到染色体的尾端,对维持染色体的长度、调节细胞增殖和凋亡起重要作用。
端粒酶主要存在于恶性肿瘤之中，一般在大多数正常组织中没有活性或活性极低，同时由于端粒酶在恶性肿瘤的发展中起着关键作用，所以通过各种途径抑制端粒酶的活性可能有效地抑制大多数肿瘤的生长，而对大多数正常细胞没有影响。这种抑制作用可以通过直接抑制端粒酶活性、抑制端粒酶RNA或端粒酶蛋白成分以及诱导肿瘤细胞发生分化等方法实现。

端粒酶与恶性肿瘤之间令人惊异的相关性使它在肿瘤的诊断和治疗上有望成为行之有效的新的靶目标。
分子量：120-130KDa

Telomeres are nucleoprotein structures at the ends of eukaryotic chromosomes. They regulate several crucial cellular functions and participate in the control of complex phenotypes, such as aging and cancer. Cell immortalization is strongly associated with the stabilization of telomere length. Therefore, it is suggested that cancer cells achieve immortalization in part through illegitimate activation of telomerase expression.
Human telomerase reverse transcriptase (hTERT) is the rate limiting catalytic subunit of telomerase. It is also responsible for addition of TTAGGG repeats to the telomere ends of the chromosome, which is important in maintaining cell immortality. In most normal human cells the expression of hTERT is very low. On the other hand, greater than 90 % of human tumors of different pathology and origins have been shown to upregulate telomerase expression, making hTERT a cancer associated target.
mol wt:120-130KDa
Also known as:
EST2; hEST2; TCS1; Telomerase associated protein 2; Telomerase Catalytic Subunit; Telomere Reverse Transcriptase; TERT; TP2; TRT

xy-0810R Fibulin 5衰老关键蛋白抗体
xy-0119R FLIP凋亡调节基因之一抗体
xy-1120R FLIP凋亡调节基因之一抗体（短型）
xy-0666R Fibronectin纤维连接蛋白抗体
xy-1170R FOS BFosB蛋白抗体
xy-1188R FRA2FRA2/FOSL2抗体
xy-0269R FoxP3叉头蛋白P3抗体
xy-0735R FGF8成纤维细胞生长因子8抗体
xy-6848R Fascin肌动蛋白结合蛋白Fascin抗体
xy-7646R FIS1线粒体裂变1蛋白抗体
xy-1275R FoxP1叉头蛋白P1抗体
xym-1265M F1 protein (YERSINIA PESTIS)鼠疫F1蛋白/鼠疫耶尔森氏菌荚膜抗原F1单克隆抗体
xy-1257R FGF5纤维母细胞生长因子5抗体
xy-6876R FMR1脆性X综合征相关蛋白AFF1抗体
xy-11010R FAM84A感觉神经蛋白1抗体
xy-9601R Frataxin线粒体型共济失调蛋白抗体
xy-8514R Fc ε RIαFC段IgE受体α多肽抗体
xy-8654R FAM81AFAM81A蛋白抗体
xy-9657R FAM78BFAM78B蛋白抗体
xy-9656R C9orf599号染色体开放阅读框59抗体
xy-9658R FAM76AFAM76A蛋白抗体
端粒酶抗体