ALK-1 / ACVRL1抗体

ALK-1 / ACVRL1抗体产品信息免疫原 : Recombinant Human ALK-1 / ACVRL1 protein (Catalog#10066-H08H)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human ALK-1 / ACVRL1 (rh ALK-1 / ACVRL1; Catalog#10066-H08H; NP_000011.2; Met1-Gln118). ALK-1 / ACVRL1 specific IgG was purified by Human ALK-1 / ACVRL1 affinity chromatography.
ALK-1 / ACVRL1抗体 Background
ALK1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. The heteromeric receptor complex consists of two types (I and II) transmembrane serine/threonine kinases, among which, constitutively active Type II receptors phosphorylate and activate type I receptors on ligand binding, and in turn, type I kinase phosphorylates down stream signal molecules including various SMAD transcriptional regulators. ALK1 shares a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail with other activin receptor-like kinase proteins. ALK1 has been suggested to be implicated in the blood vessel development and repair. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
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