CLEC3B / Tetranectin抗体

CLEC3B / Tetranectin抗体产品信息免疫原 : Recombinant Mouse CLEC3B / Tetranectin protein (Catalog#50700-M08H)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Mouse CLEC3B / Tetranectin (rM CLEC3B / Tetranectin; Catalog#50700-M08H; P43025; Met1-Val202). CLEC3B / Tetranectin specific IgG was purified by Mouse CLEC3B / Tetranectin affinity chromatography.
CLEC3B / Tetranectin抗体 Background
Tetranectin, also known as C-type lectin domain family 3, member B (CLEC3B), is a homotrimeric plasma and extracellular-matrix protein that binds plasminogen and complex sulphated polysaccharides including heparin. In terms of primary and tertiary structure, Tetranectin is related to the collectin family of Ca(2+)-binding C-type lectins. Tetranectin is encoded in three exons. Exon 3 encodes the carbohydrate recognition domain, which binds to kringle 4 in plasminogen at low levels of Ca(2+). Exon 2 encodes an alpha-helix, which is necessary and sufficient to govern the trimerization of Tetranectin by assembling into a triple-helical coiled-coil structural element. Tetranectin has been suggested to play a role in tissue remodeling, due to its ability to stimulate plasminogen activation and its expression in developing tissues such as developing bone and muscle. Tetranectin enhances plasminogen activation by a tissue-type plasminogen activator so that it has been suggested to play a role in tissue remodeling. TN may play a role in neurological diseases and may serve as a diagnostic aid in multiple sclerosis (MS). The serum or saliva Tetranectin may serve as a potential biomarker for metastatic oral squamous cell carcinoma (OSCC). Decreased plasma Tetranectin or increased Tetranectin in stroma of cancers correlates with cancer progression and adverse prognosis.
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