Tetranectin / CLEC3B抗体

Tetranectin / CLEC3B抗体产品信息
免疫原 : Recombinant Human Tetranectin / CLEC3B protein (Catalog#12735-H08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 006
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human Tetranectin / CLEC3B (rh Tetranectin / CLEC3B; Catalog#12735-H08H; AAX37102.1; Met1-Val202).
Tetranectin / CLEC3B抗体 Background
Tetranectin, also known as C-type lectin domain family 3, member B (CLEC3B), is a homotrimeric plasma and extracellular-matrix protein that binds plasminogen and complex sulphated polysaccharides including heparin. In terms of primary and tertiary structure, Tetranectin is related to the collectin family of Ca (2+)-binding C-type lectins. Tetranectin is encoded in three exons. Exon 3 encodes the carbohydrate recognition domain, which binds to kringle 4 in plasminogen at low levels of Ca (2+). Exon 2 encodes an alpha-helix, which is necessary and sufficient to govern the trimerization of Tetranectin by assembling into a triple-helical coiled-coil structural element. Tetranectin has been suggested to play a role in tissue remodeling, due to its ability to stimulate plasminogen activation and its expression in developing tissues such as developing bone and muscle. Tetranectin enhances plasminogen activation by a tissue-type plasminogen activator so that it has been suggested to play a role in tissue remodeling. TN may play a role in neurological diseases and may serve as a diagnostic aid in multiple sclerosis (MS). The serum or saliva Tetranectin may serve as a potential biomarker for metastatic oral squamous cell carcinoma (OSCC). Decreased plasma Tetranectin or increased Tetranectin in stroma of cancers correlates with cancer progression and adverse prognosis.
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