ANXA5 / Annexin Ⅴ / Annexin A5

ANXA5 / Annexin Ⅴ / Annexin A5抗体产品信息免疫原 : Recombinant Human ANXA5 / Annexin Ⅴ / Annexin A5 protein (Catalog#10448-HNAE)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human ANXA5 / Annexin Ⅴ / Annexin A5 (rh ANXA5 / Annexin Ⅴ / Annexin A5; Catalog#10448-HNAE; P08758; Met1-Asp320). Total IgG was purified by Protein A affinity chromatography.
ANXA5 / Annexin Ⅴ / Annexin A5抗体 Background
Annexin Ⅴ, also known as Annexin A5 (ANXA5), belongs to a family of Ca2+ binding proteins that undergo reversible Ca2+-dependent binding to phospholipids (PLs) that are located on the cytosolic face of the plasma membrane. They are abundant intracellular proteins, and several different annexin gene products are expressed in all mammalian cells examined to date. Antithrombotic effect exerted by Annexin A5 (ANXA5) is thought to be mediated mainly by forming a mechanical shield over phospholipids (PLs) reducing availability of PLs for coagulation reactions. However, more specific properties of ANXA5 might be of importance for its antithrombotic function. Such examples include downregulation of surface-expressed tissue factor (TF), as well as upregulation of urokinase-type plasminogen activator (uPA) by ANXA5. Also, interation of ANXA5 with ligands involved in hemostasis, such as sulfatide and heparin, has been demonstrated.
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