(MERS-CoV) Spike抗体

(MERS-CoV) Spike抗体产品信息免疫原 : Recombinant novel coronavirus (MERS-CoV) Spike Protein (ECD, aa 1-1297) (Catalog#40069-V08B)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant novel coronavirus (MERS-CoV) Spike Protein (Catalog#40069-V08B; AFS88936.1; Met1-Trp1297). Total IgG was purified by Protein A affinity chromatography.
(MERS-CoV) Spike抗体 Background
The spike protein is one of the four major structural proteins of the coronavirus. Coronavirus entry is mediated by the viral spike protein. The 180-kDa oligomeric spike protein of the murine coronavirus mouse hepatitis virus strain A59 is posttranslationally cleaved into an S1 receptor binding unit and an S2 membrane fusion unit. Both biochemical and functional data show that the coronavirus spike protein is a class I viral fusion protein.HCoV-EMC is a novel coronavirus isolated from a Saudi patient presenting with pneumonia and renal failure in June 2012. Genome sequencing showed that this virus belongs to the group C species of the genus betacoronavirus and phylogenetically related to the bat coronaviruses HKU4 and HKU5 previously found in lesser bamboo bat and Japanese Pipistrelle bat of Hong Kong respectively. HCoV-EMC has been identified as a highly lethal virus that could be passed from animals to humans very easily. The virus, like other coronaviridae, has the potential to infect bats and pigs in addition to humans. HCoV-EMC is related to the causative agent of SARS (severe acute respiratory syndrome), SARS coronavirus. and also may be even more infectious as it does not use the human receptor protein ACE2. The receptor used by HCov-EMC has not been identified. Symptoms of infection include kidney failure and severe pneumonia. The animal source has still not been identified but may circulate among populations of bats.
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