IL7RA / CD127抗体

IL7RA / CD127抗体产品信息免疫原 : Recombinant human IL7RA protein ( Catalog#10975-H08H )

抗体类型: Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
5H10B5D6
抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human IL7RA ( rh IL7RA ; Catalog#10975-H08H; NP_002176.2 ; Met 1- Gly 236 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
IL7RA / CD127抗体背景综述
Interleukin 7 Receptor alpha (IL-7Rα), also known as CD127, is a hematopoietin receptor superfamily member that plays an important role in lymphocyte differentiation, proliferation, and survival. IL-7Rα is majorly expressed on T cells and their precursors, and early in B cell development as well, prior to the appearance of surface IgM. Mature human IL-7Rα consists of a 219 aa extracellular domain (ECD) with one fibronectin type-III domain and a WSxWS motif, a 25 aa transmembrane segment, and a 195 aa cytoplasmic domain. Within the ECD, human IL-7Rα shares 67% aa sequence identity with mouse IL-7Rα. Mutations in the human IL-7Rα gene cause a type of severe combined immunodeficiency in which the major deficiencies are in T cell development, whereas B and NK cells are relatively normal in number. Therefore, the IL-7Rα is critically required for the proper development and function of lymphoid cells. In addition to IL-7, IL-7Rα also associates with TSLPR to form the functional receptor for thymic stromal lymphopoietin (TSLP) which indirectly regulates T cell development by modulating dendritic cell activation. Dynamic regulation of IL-7Rα is important for the generation of appropriate immune responses.
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