CD22抗体

CD22抗体产品信息免疫原 : Recombinant Human CD22 protein (Catalog#11958-H08H)

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 07
抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD22 (rh CD22; Catalog#11958-H08H; P20273-1; Met 1-Arg 687). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
CD22抗体 Background
CD22 is a molecule belonging to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family. It is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The CD22 cell-surface adhesion molecule is capable of modulating B lymphocyte antigen receptor (BCR)-mediated signals, as well as the generation of BCR-independent signals. CD22 is an inhibitory coreceptor of the B-cell receptor (BCR), and plays a critical role in establishing signalling thresholds for B-cell activation. CD22 recruits the tyrosine phosphatase Src homology 2 domain-containing phosphatase 1 (SHP-1) to immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and inhibits B-cell receptor (BCR)-induced Ca2+ signaling on normal B cells. CD22 interacts specifically with ligands carrying alpha2-6-linked sialic acids. Interaction of CD22 to ligands in trans can regulate both B-cell migration as well as the BCR signaling threshold. However, a more complex role for CD22 has recently emerged, including a central role in a novel regulatory loop controlling the CD19/CD21-Src-family protein tyrosine kinase (PTK) amplification pathway that regulates basal signaling thresholds and intensifies Src-family kinase activation after BCR ligation. CD19 regulates CD22 phosphorylation by augmenting Lyn kinase activity, while CD22 inhibits CD19 phosphorylation via SHP-1. Thus, the CD19/CD22 loop may be a potential therapeutic target in autoimmune disease for modulating B cell signaling.
CD22抗体相关产品如下：xy-13520R GPR146G蛋白偶联受体146抗体
xy-13521R GPR17G蛋白偶联受体17抗体
xy-13522R GPR19G蛋白偶联受体19抗体
xy-13523R GPR20G蛋白偶联受体20抗体
xy-13524R GPR21G蛋白偶联受体21抗体
xy-13525R GPR22G蛋白偶联受体22抗体
xy-13526R GPR25G蛋白偶联受体25抗体
xy-13527R GPR26G蛋白偶联受体26抗体
xy-13528R GPR27G蛋白偶联受体27抗体
xy-13529R GPR3G蛋白偶联受体3抗体
xy-13530R GPR31G蛋白偶联受体31抗体
xy-13531R GPR32G蛋白偶联受体32抗体
xy-13532R GPR34G蛋白偶联受体34抗体
xy-13533R GPR35G蛋白偶联受体35抗体
xy-13534R GPR37G蛋白偶联受体37/帕金森相关内皮素受体样受体抗体
xy-13535R GPR40G蛋白偶联受体40抗体
xy-13536R GPR43G蛋白偶联受体43抗体
xy-13537R GPR44G蛋白偶联受体44抗体
xy-13538R GPR45G蛋白偶联受体45抗体
xy-12352R GSC同源盒蛋白GSC抗体
xy-13328R Gemin 4脊髓性肌萎缩症蛋白Gemin4抗体
xy-13329R Gemin 5脊髓性肌萎缩症蛋白Gemin5抗体
xy-13330R Gemin 7脊髓性肌萎缩症蛋白Gemin7抗体
xy-13331R GEMGTP结合丝裂原诱导T细胞蛋白抗体
xy-13332R GEMC1染色体卷曲螺旋域包含蛋白1抗体
xy-13333R Gemin 6脊髓性肌萎缩症蛋白Gemin6抗体
xy-13336R phospho-GFAP (Ser38)磷酸化胶质纤维酸性蛋白抗体
xy-13337R GFI1自主生长因子GFI1抗体
xy-10079R GPR109AG蛋白偶联受体109A抗体
xy-13343R GGA1γ-衔接蛋白相关蛋白1抗体
xy-13344R GGA2γ-衔接蛋白相关蛋白2抗体
xy-13345R GGA3γ-衔接蛋白相关蛋白3抗体
xy-13347R GGN配子生成素抗体
xy-13348R GGT2 heavy chainγ谷氨酰转肽酶2重链抗体
xy-13349R GGT5 heavy chainγ-谷氨酰转肽酶5重链抗体