DDC / AADC抗体

DDC / AADC抗体产品信息免疫原 : Recombinant human DDC protein ( Catalog#10560-H08B )

抗体类型: Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
10H9E8E7
抗体宿主 : Mouse IgG2b
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, insect cell-derived, recombinant human DDC / AADC ( rh DDC ; Catalog#10560-H08B ; NP_000781.1 ; Met 1 - Glu 480 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
DDC / AADC抗体背景综述
Dopa Decarboxylase (DDC), also known as AADC and Aromatic-L-amino acid decarboxylase, is a 54 kDa member of the group II decarboxylase family of proteins.It is a vitamin B6-dependent homodimeric enzyme that catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines. Since L-DOPA is regularly used to treat the symptoms of Parkinson's disease, the catalytic pathway is of particular research interest. Defects of DDC are associated with severe developmental delay, oculogyric crises (OGC), as well as autosomal recessive disorder AADC deficiency, an early onset inborn error in neurotransmitter metabolism which can lead to catecholamine and serotonin deficiency.
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