IL22RA2 / IL22BP抗体

IL22RA2 / IL22BP抗体产品信息免疫原 : Recombinant human IL22BP protein ( Catalog#11025-H08H )

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 9A11E4F7

抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human IL22RA2 / IL22BP ( rh IL22BP ; Catalog#11025-H08H ; NP_851826.1 ; Met 1 - Pro 231 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
IL22RA2 / IL22BP抗体背景综述
Interleukin-22 receptor subunit alpha-2 (IL22RA2), also known as interleukin-22-binding protein (IL22BP), is a subunit of the receptor for interleukin 22. IL22BP belongs to the type I I cytokine receptor family and contains 3 fibronectin type-III domains. The class II cytokine receptor family includes the receptors for IFN-alphabeta, IFN-gamma, IL-10, and IL-10-related T cell-derived inducible factor/IL-22. IL22BP is expressed in a range of tissues, including those in the digestive, female reproductive, and immune systems. It is expressed in placenta, spleen, breast, skin and lung. It is also detected in intestinal tract, testis, brain, heart and thymus. The dominant cell types expressing IL22BP were mononuclear cells and epithelium. IL22BP may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important roles in immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptor have been discovered, a membrane-bound receptor and a soluble receptor.
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