FLT3 / FLK2 / CD135抗体

FLT3 / FLK2 / CD135抗体产品信息免疫原 : Recombinant human FLT3 protein ( Catalog# 10445-H08H )

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 4G7E6B7

抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human FLT3 ( rh FLT3 ; Catalog#10445-H08H ; NP_004110.2 ; Met 1 - Asn 541 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography
FLT3 / FLK2 / CD135抗体背景综述
FL cytokine receptor, also known as tyrosine-protein kinase receptor FLT3, Stem cell tyrosine kinase 1, STK-1, FLT3 and CD135, is a single-pass type I membrane protein. CD135 belongs to the protein kinase superfamily and the CSF-1/PDGF receptor subfamily. It contains one Ig-like C2-type domain and one protein kinase domain. CD135 is an important cell surface marker used to identify certain types of hematopoietic progenitors in the bone marrow. Specifically, multipotent progenitors (MPP) and common lymphoid progenitors (CLP) express surface CD135 at high levels. This marker is therefore used to differentiate hematopoietic stem cells (HSC), which are CD135 negative, from MPPs, which are CD135 positive. Signaling through CD135 plays a role in cell survival, proliferation, and differentiation. CD135 is also important for lymphocyte (B cell and T cell) development, but not for the development of other blood cells (myeloid development). Identified as a proto-oncogene, the mutations of FLTS gene are associated with certain carcinomas.
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