HSP27抗体

HSP27抗体产品信息免疫原 : Recombinant Human HSP27 Protein (Catalog#10351-H08E)

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 4E 8H3

抗体宿主 : Mouse IgG2b
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant Human HSP27 (rh HSP27; Catalog#10351-H08E; NP_001532.1; Met 1 – Lys 205). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
HSP27抗体 Background
Heat shock proteins (HSPs) are a group of highly conserved stress response proteins which primarily function as molecular chaperones, and are involved in a variety of biological processes including thermotolerance, inhibition of apoptosis, regulation of cell development and cell differentiation, as well as signal transduction. As a member of the chaperones, HSP27 appears in many cell types, especially all types of muscle cells, and is suggested to play an essential role in the differentiation of tissues. HSP27 has a characteristic and highly conserved amino acid sequence at the C-terminus, the so-called α-crystallin-domain which is important for the formation of stable dimers, and it is demonstrated that the oligomerization status is connected with the chaperone activity. HSP27 is also identified as an anti-apoptotic molecule. It interacts with the outer mitochondrial membranes and interferes with the activation of cytochrome c/Apaf-1/dATP complex and therefore inhibits the activation of procaspase-9 and procaspase-3. Furthermore, HSP27 also exerts functions in protecting actin filaments from fragmentation and the activation of the certain proteasome.
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