CA14 / Car14抗体

CA14 / Car14抗体产品信息免疫原 : Recombinant human CA14 protein ( Catalog#10458-H08H )

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 004
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human CA14 / Car14 extracellular domain ( rh CA14 ; Catalog#10458-H08H ; NP_036245.1 ; Met 1 - Met 290 ).
CA14 / Car14抗体背景综述
Carbonic anhydrases (CAs) are zinc-binding metalloenzymes that catalyze the reversible hydration of carbon dioxide to form HCO3- and protons. Fifteen CA isoforms have been reported sofar. CA I, CA II, CA III, CA VII, and CA XIII are cytosolic enzymes, whereas CA IV, CA IX, CA XII, CA XIV, and CA XV are membrane-associated isoforms. CA XIV is a polypeptide consisting of an extracellular N-terminal catalytic domain, a membrane-spanning segment and a short intracellular C-terminal segment with several potential phosphorylation sites. The CA XIV protein is expressed in the brain on plasma membranes of neuronal bodies and axons, in the kidney preferentially on the apical membranes of proximal tubules, and in the liver on the plasma membranes of hepatocytes. CA14, together with CA4, play important roles in the regulation of intracellular pH in hippocampal neurons by facilitating AE3-mediated Cl--HCO3- exchange.
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