Galectin-1抗体

Galectin-1抗体产品信息免疫原 : Recombinant Human Galectin-1 protein (Catalog#10290-HNAE)

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 04
Ig Type : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Galectin-1 (rh Galectin-1; Catalog#10290-HNAE; NP_002296.1; Met 1-Asp 135). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Galectin-1抗体 Background
Galectin-1 (Gal-1, GAL1), the first identified member of the β-galactoside-bindinganimal lectin family, and exists as a homodimer of a single carbohydrate-recognition domain. Galectin-1 is expressed in a variety of cell types, including thymic epithelial cells, endothelial cells, dendritic cells, macrophages, fibroblasts, and bone marrow stromal cells. There is increased galectin-1 expression in many types of cancer, including colon, breast, ovary and prostate carcinomas. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. It is revealed that Galectin-1 can induce apoptosis of activated human T cells and human T leukaemia cell lines, while resting T cells also bound galectin-1, but did not undergo apoptosis. Galectin-1 modulates inflammatory responses and contributes to tumor progression and immune cell homeostasis. Galectin-1 regulates the inflammatory responses of neutrophils, mast cells, and macrophages and also associates with components of the complement system. Galectin-1 is thus suggested to act as an autocrine negative regulatory "cytokine", killing T cells to terminate an immune response.
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