IL13RA1 / CD213a1抗体

IL13RA1 / CD213a1抗体产品信息免疫原 : Recombinant human IL13RA1 protein ( Catalog#10943-H08H )

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 26
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human IL13RA1 extracellular domain ( rh IL13RA1 ; Catalog#10943-H08H ; NP_001551.1 ; Met 1 - Thr 343 ).
IL13RA1 / CD213a1抗体背景综述
Interleukin 13 receptor alpha 1 (IL13Rα1), also known as CD213A1 (cluster of differentiation 213A1), is a subunit of the IL-13 receptor, and binds IL13 with a low affinity by itself. IL-13 is capable of binding two types of receptor: the heterodimer, composed of the IL13 Rα1 and the IL4Rα , transducing the IL13 signals; and the IL13Rα2, acting as a nonsignaling "decoy" receptor. IL13 Rα1 forms a functional receptor complex for IL-13 with IL4 receptor alpha (IL4Rα), a subunit shared by IL13 and IL4 receptors, transducing an IL13-dependent proliferative signal. IL13 Rα1 has also been shown to serve as an alternate accessory protein to the common cytokine receptor gamma chain for IL4 signaling, but cannot replace the function of gamma C in allowing enhanced IL2 binding activity. The human IL13 Rα1 cDNA encodes a 427 aa residue precursor protein, and the extracellular domain is composed of three fibronectin type III domains, D1, D2, and D3, of which the last two comprise the cytokine receptor homology modules (CRHs). Human and mouse IL13 Rα1 share 76% aa sequence identity.
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