Basigin / BSG / CD147抗体

Basigin / BSG / CD147抗体产品信息免疫原 : Recombinant mouse CD147 protein ( Catalog#50332-M08H )

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 041
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant mouse CD147 ( rM CD147; Catalog#50332-M08H ; NP_001070652.1 ; Met 1 - Arg 209 ).
Basigin / BSG / CD147抗体背景综述
Mouse CD147, also known as BSG or EMMPRIN, is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. CD147 is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including sperm-atogenesis, embryo implantation, neural network formation, and tumor progression. Enriched on the plasma memebrane of many human cancer ( breast cancer, lymphoma, oral squamous cell carcinoma, glioma, melanoma, lung, bladder and kidney carcinomas ) cells, CD147 induces the production and release of matrix metalloproteinases in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. CD147 is a key molecule related to mouse blastocyst implantation. The high level of CD147 expression in the blastocyst may also play a role during embryo implantation.
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