KIM-1 / TIM1 / HACVR1抗体

KIM-1 / TIM1 / HACVR1抗体产品信息免疫原 : Recombinant Rat KIM-1 / TIM1 / HAVCR1 Protein ( Catalog #80003-R07H )
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 104
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Rat ( rR KIM-1 / TIM1 / HAVCR1; Catalog #80003-R07H; aa18-238; NP_775172.1).
KIM-1 / TIM1 / HACVR1抗体 Background
Mouse hepatitis A virus cellular receptor 1 (HAVCR1), also known as T cell immunoglobulin and mucin domain-containing protein 1(TIMD1)and T cell membrane protein 1(TIM1), is a member of the TIM family , an immunologically important group of receptors that is conserved in vertebrates. TIM1 is widely expressed with highest levels in kidney and testis. It has been shown that mouse HAVCR1 is expressed by stimulated T-cells during primary antigen stimulation and associates with immunomodulatory properties. TIM1 is a type 1 integral membrane glycoprotein, and in the ECD contains one V-type I?g-like domain extended above the cell surface by a mucin-like domain characterized by a variable number of threonine, serine, and proline (TSP) hexameric repeats. Extensive O-linked glycosylation resulted in the 70-80 kDa molecular mass more higher than the calculated MW(33KDa). TIM1 plays a critical role in T-helper cell development and the regulation of asthma and allergic diseases. In addition to HAV, another identified ligand for TIM1 is TIMD4. Mouse TIM1 ECD shares 50% and 80% amino acid sequence homology with human and rat TIM1 ECD rexpectively.
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