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- Abcam
- 中国/美国/德国
- xy10101-R028-F
- 2025年07月12日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
CD55 / DAF抗体
Reagents : FITC-conjugated rabbit monoclonal antibody
Clone ID : 028
抗体宿主 : Rabbit IgG
Concentration : 5 μl/Test, 0.2 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human CD55 / DAF (rh CD55 / DAF; Catalog#10101-H08H; NP_000565.1; Met 1-Ser 353) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
CD55 / DAF抗体 Background
CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. This 70-75 kDa glycoprotein CD55 containing four SCR modules is involved in the regulation of the complement cascade. It interferes with the functions of C3 and C5 convertases in both the classical and alternative pathways by preventing the assembly of the C3bBb complex or accelerating the disassembly of preformed convertase, and thus disrupts the cascade and protects the host cells from damage. Antigens present on the CD55/DAF constitute determinant for the Cromer blood group system. CD55/DAF has been identified as a ligand for an activation-associated, seven-transmembrane lymphocyte receptor, CD97, which is a receptor mediating attachment and infection of several viruses and bacteria. In addition, it has been shown that CD55/DAF regulates the interplay between complement and T cell immunity in vivo, and thus may be implicated in immune and tumor biology. There are two variants of CD55 encoded by alternatively spliced transcripts, the predominant variant is a GPI-anchored membrane form ubiquitously expressed on cells exposed to plasma complement proteins, whereas a soluble form present at much lower level.
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xy-8060R MOP5单核细胞蛋白5抗体
xy-9002R SAMD9SAMD9蛋白抗体
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xy-7770R SEPT10细胞分化蛋白SEPT10抗体
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xy-9581R SHARPIN线性泛素链相关蛋白SHARPIN抗体
xy-9003R SAMD7SAMD7蛋白抗体
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文献和实验CD55 分子 CD55 常用单克隆抗体或代号： 143- 30,BRIC110,BRIC123;(DAF) 主要表达细胞： 广泛 [NL] 分子质量(kDa)和结构： gp70(GPI连接) 功 能： 衰变加速因子,调节补体活化 CD55 Aka decay accelerating factor Binds C3bBb (alternative pathway
网络 三、促衰变因子（CD55） 促衰变因子（decay accelerating factor,DAF）是Nicholson-Weller等（1981）用正丁醇提取后，再以层析法从人和豚鼠红细胞基质中纯化的一种膜蛋白。因其具有促进C3转化酶衷变的活性故名。经在还原条件下做SDS-PAGE并以过碘酸
脾细胞与小鼠骨髓瘤细胞（P3-X63/Ag8）融合，融合的细胞既获得了亲代脾细胞分泌特异性抗体的特性，又具有骨髓瘤细胞大量繁殖的能力，成为一种既能分泌特异性抗体又能长命的杂交瘤细胞。该技术为抗体的分子生物学研究提供了全新的手段。极大地促进了免疫学，遗传学，分子生物学的快速发展。 但传统抗体目前也面临诸多问题，如： 每使用一管新抗体都需要进行滴定测试； 多种同型对照，实验设计繁琐； 需要添加Fc阻断试剂； 抗体不佳，阳性细胞群不明显； 抗体作为细胞生物学和生物化学中最重要的试剂之一，科学界每年在这类
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