TRAF6

三句话读懂一篇 CNS：每天要走多少步，才能降低死亡风险？这种蔬菜的完整基因组终被破译

起关键作用。 2022 年 3 月 1 日，武汉大学李姝及舒红兵等多团队合作在 PNAS 发表研究论文 Reciprocal regulation of IL-33 receptor–mediated inflammatory response and pulmonary fibrosis by TRAF6 and USP38。 该研究将泛素特异性蛋白酶 38（USP38）鉴定为 IL-33R 介导的信号传导的负调节剂，缺乏 Usp38 的小鼠更容易受到炎症损伤肺纤维和死亡，解析了 TRAF6

LPS介导的MAPK信号通路

and p38. Activation of the NFkappB pathway is complex. It requires activation of phosphatidylinositol-3-kinase (PI3K) upstream of IkappaBalpha degradation. A second NFkappaB activation pathway follows the sequence: TLR4, MyD88, TIR, IRAK1, TRAF6, NIK, IKK

白介素33信号通路图

of metalloproteinase; TNF, tumor necrosis factor. IL-33 signaling occurs via the ST2L receptor. Binding of IL-33 to ST2L induces the recruitment of IL-1RAcP and activation of intraCell ular signaling pathways including MyD88 and TRAF6-dependent activation