CHOLERA TOXIN

霍乱毒素 cholera toxin

霍乱菌产生的外毒素，已经证明它是能引起腹泻的毒素。也称为霍乱肠毒素（cholera enteroto－ xin）或霍乱原（ choleragen）。可从霍乱菌培养液的上清液提纯的结晶，为分子量约 8万 4千的简单蛋白质，由分子量约 2万 8千的 A亚单位 1分子和分子量约 1万 1千的 B亚单位 5分子所构成。 A亚单位为起表达作用的活性分子，更可分为 A1 及 A2 二部分， A1 为活性部分。其作用机理是由于使腺苷酸环化酶的调控分子（ G蛋白） ADP核糖基化，从而失掉三磷酸鸟

A Biochemical Method for Tracking Cholera Toxin Transport From Plasma Membrane to Golgi and Endoplasmic Reticulum

Asiatic cholera is a rapidly progressing disease resulting in extreme diarrhea and even death. The causative agent, cholera toxin, is an AB5 -subunit enterotoxin produced by the bacterium Vibrio cholera . The toxin must enter the intestinal

Cholera

Few diseases invoke public fear as readily as cholera. In its most severe state, cholera can cause death from hypotensive shock within 12 h of the first symptom. Cholera typically occurs in epidemics, spreading rapidly within the community