UbcH5a 蛋白(人) (His标签) | UbcH5a

【产品形式】：艾美捷为您提供的UbcH5a 蛋白(人) (His标签)形式为20mM Tris-Cl, pH 8.0, 1mM DTT

【背景资料】：UbcH5a, also known as UBE2D1, is a member of the ubiquitin E2 conjugating enzyme family, essential components of the ubiquitin cascade. The selectivity of the ubiquitin cascade for a particular substrate protein relies on the interaction between the E2 conjugating enzyme (of which a cell contains relatively few) and an ubiquitin E3 ligase, of which over 600 have been identified to date. The specific E2-E3 pair required for ubiquitination of a particular substrate protein in vivo may also control the type of ubiquitin modification (mono-, multi-, poly-ubiquitin), the exact substrate lysine residue(s) to be modified and, in the case of polyubiquitination, the chain length and lysine linkage type. UbcH5a has been shown to interact in vivo with the breast cancer associated DNA damage response enzymes BARD1 and BRCA1 and to be involved in the E6AP mediated ubiquitination of p53. In vitro it acts as a promiscuous E2 and is able to interact with a range of different E3 enzymes and participate in polyubiquitin chain synthesis. Recombinant human UbcH5a protein expressed with a N-terminal His-tag. Protein has utility in ubiquitination reactions, polyubiquitin chain synthesis, identification of substrate specific E2-E3 pairs and determination of E2 polyubiquitin linkage specificity.

英国Viva Bioscience公司是一家研发、生产并销售蛋白降解相关产品的公司。其产品主要用于细胞自噬、泛素化和蛋白酶体研究（也覆盖其他蛋白降解相关的产品），其产品价格合理、质量可靠且具有创新性。目前VIVA Bioscience提供逾460种产品，涉及细胞自噬、蛋白泛素化和讲解相关的所有试剂盒、蛋白、底物以及多种抑制剂、激活剂等全系列产品。作为多家进口品牌的中国区域总代理，艾美捷科技与Viva Bioscience一道为中国科研工作者们提供更好、更新的自噬、泛素化和蛋白酶体等研究工具。

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