人类蛋白质组芯片（20000种蛋白，40000点）

为科学创新领航

让临床科研不再难

体必康集团依托中国科学院生物物理研究所搭建了全方位的科研平台，将组学分析、分子生物学、生物化学及细胞、动物生物学等多技术整合。为阐明疾病机制、探索预防和治疗方法提供整体技术方案。

体必康科研自主研发并转化了一系列蛋白质组学技术（从基因克隆、载体构建、蛋白表达，到芯片制备、样本检测及分析报告等一系列标准化、专业化、工业化的蛋白质芯片研发和服务技术），得到了行业的广泛认可。除此之外，体必康科研平台还提供其他组学技术服务，以健康中国为己任，致力于“让临床科研不再难”，与临床医生一起，从临床问题出发，系统全面地解析生命过程的发生、发展机制。

产品货号：HM-1001 

产品性能
人蛋白质：20,240种
一张芯片上的点阵数目：1
点样环境：温度4-8℃，湿度30%~40%
芯片基片：PATH，尺寸为75*25 mm
点直径：~60微米
样品重复：每个样品重复两个点
点体积：0.5~1 nl/点
芯片点制后处理：4℃过夜固定后-80℃长期保存

产品应用
1. 药物作用靶标发现及药物作用机理研究
2. 蛋白质-蛋白质相互作用研究
3. 蛋白质翻译后修饰研究
4. 非编码RNA作用机制研究
5. 蛋白质与DNA相互作用研究
6. 抗体特异性筛选
7. 酶底物研究

发表的文章

Yang, Lina, et al. "Identification of serum biomarkers for gastric cancer diagnosis using a human proteome microarray." Molecular & Cellular Proteomics (2015): mcp-M115. 

Zhang, Hai-nan, et al. "Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic." Proceedings of the National Academy of Sciences 112.49 (2015): 15084-15089.

Hu, C et al. (2015) Autoantibody Profiling on Human Proteome Microarray for Biomarker Discovery in Cerebrospinal Fluid and Sera of Neuropsychiatric Lupus. PLoS One 10:e0126643.

Liu, S et al. (2015) Characterization of monoclonal antibody's binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119. 

Fan, Q et al. (2014). Identification of proteins that interact with alpha A-crystallin using a human proteome microarray. Mol Vis 20:117–124. 

Deng, RP et al. (2014). Global Identification of O-GlcNAc Transferase (OGT) Interactors by a Human Proteome Microarray and the Construction of an OGT Interactome.Proteomics 14(9): 1020-30. doi: 10.1002/pmic.201300144. Epub 2014 Mar 25.0.

Ma, TM et al. (2014) Serine Racemase Regulated by Binding to Stargazin and PSD-95: Potential NMDA-AMPA Glutamate Neurotransmission Cross-talk. J Biol Chem pii: jbc.M114.571604. [Epub ahead of print]; First Published on August 27, 2014. 

Barry G et al. (2013). The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing. Molec Psychiatry Apr 30. doi: 10.1038/mp.2013.45. ePub ahead of print.

Lee YI et al. (2013). Protein microarray characterization of the S-nitrosoproteome. Mol Cell Proteomics 13:63-72. 

Chen Y et al. (2013). Bcl2-associated Athanogene 3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity. Mol Cell Proteomics 12(10):2804-19.

Donnelly CJ et al. (2013). RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention. Neuron 80(2):415-28. 

Fan B et al. (2013). A human proteome microarray identifies that the heterogeneous nuclear ribonucleoprotein K (hnRNP K) recognizes the 5’ terminal sequence of the hepatitis C virus RNA. Mol Cell Proteomics. 13(1):84-92. 

Tarrant MK et al. (2012). Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis. Nat Chem Biol 8(3):262-9. 

Jeong JS et al. (2012). Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253.

Huang Y. et al. (2012). Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance. Cell Cycle 11(12):2367-79. 

Hu CJ et al. (2012). Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays. Mol Cell Proteomics 11(9):669-80.