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- 克隆性：
单克隆
- 抗体英文名：
Anti-WIP1(WPP-DOMAIN
- 抗体名：
原癌基因WIP1抗体
PPM1D (Wip) is a serine/threonine phosphatase implicated in cell cycle control, spermatogenesis, and lymphoid cell function. The predicted 605-amino acid PPM1D protein contains 2 putative nuclear localization signals and 3 regions conserved in serine/threonine PP2C phosphatases, as well as characteristics of a type 2C phosphatase, including magnesium dependence and relative insensitivity to okadaic acid. PPM1D expression is induced in response to ionizing radiation in a p53-dependent manner. The accumulation of PPM1D mRNA following ionizing radiation is rapid and transient, and PPM1D protein is localized to the nucleus. PPM1D may contribute to growth inhibitory pathways activated in response to DNA damage in a p53-dependent manner. PPM1D inhibits phosphorylation of the p38 mitogen-activated (MAP)kinase protein. Through p38 MAPK, PPM1D modulates the CDKN2A tumor-suppressor locus. This gene is located in a chromosomal region known to be amplified in breast cancer, (located at 17q22-q23), is amplified in human breast tumor cell lines and in approximately 11% of primary breast tumors, and appears to lead to cell transformation by abrogating p53 tumor suppressor activity. Inactivation of the p38 MAPK through PPM1D overexpression resulting from PPM1D amplification may contributes to the development of human cancers by suppressing p53 activation. PPM1D null mice have increased susceptibility to pathogens and reduced male fertility and longevity.
mol wt:67kDa
Other Aliases:
WPP-DOMAIN INTERACTING PROTEIN 1; EC 3.1.3.16; p53 induced protein phosphatase 1; PP2C delta; PP2CD; protein phosphatase 1D magnesium-dependent delta isoform; Protein phosphatase 2C delta isoform; Protein phosphatase 2C isoform delta; Protein phosphatase magnesium dependent 1 delta; WIP 1; WIP1; AV338790; PPM1D
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xy-0297M-AF647 Mouse Anti-human IgG/Alexa Fluor 647Alexa Fluor 647标记的小鼠抗人IgG
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文献和实验Bcl-2原癌基因被认为是哺乳动物细胞凋亡过程中的负调控剂。本法采用鼠抗Bcl-2单克隆抗体，可通过免疫组化或免疫细胞化学的方法用于检测组织或细胞中的Bcl-2，或者通过Western blots检测细胞粗提物。 样本来源 1. 离心细胞； 2. 细胞涂片、冰冻或石蜡包埋组织切片； 3. 细胞粗提物。 材料与试剂 1. 鼠抗Bcl-2单克隆抗体； 2. 碱性磷酸酶－抗碱性磷酸酶（APAAP）； 3. PBS缓冲液 操作步骤 1. 标本固定：用丙酮
【求助】免疫组化, FISH, CGH, LOH, MSI, 克隆性重排等的应用范围及应用”盲点”
性 （2）对疾病的预后和治疗的意义 （3）癌基因蛋白的应用 （4）对肿瘤增生程度的评价 ki67 PCNA （5）微小病灶的发现 微小癌 微小病灶（如羊水栓塞） （6）在肿瘤分期上的意义 （7）指导肿瘤治疗 （8）免疫性疾病的辅助诊断 （9）病原微生物的检测 应用“盲点”：由于抗体稀释度、多克隆抗体特异性问题、试剂盒选择、操作中时间温度染色过程等因素
癌基因和突变型抑癌基因表达的肿瘤抗原 在不同致癌因素和特定条件下，原癌基因可被激活，抑癌基因可发生突变，由此出现的异常表达产物可导致正常细胞癌变。现已发现人类肿瘤中存在着癌基因或突变型抑癌基因，并检测到相应的编码蛋白。这类蛋白在胞内经处理分解为不同小肽，通过MHCI类分子提呈可作为肿瘤特异性抗原肽被T细胞所识别，激活CTL反应。 (1)癌基因编码蛋白：如突变的FaS基因编码一种189氨基酸残基的蛋白质，分子质量为21kDa
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