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- 克隆性：
单克隆
- 抗体英文名：
Anti-mucin4/Muc4(hum
- 抗体名：
粘蛋白-4抗体
粘蛋白-4抗体产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）
粘蛋白-4抗体产品介绍
肿瘤生物标志Tumor biomarkers
MUC4 (Mucin 4) is a high molecular weight transmembrane mucin that is overexpressed in many carcinomas and is a risk factor associated with a poor prognosis. MUC4 has been found to be a heterodimeric glycoprotein complex that consists of ASGP-1 (ascites sialoglycoprotein-1), an O-glycosylated mucin subunit, and ASGP-2, an N-glycosylated transmembrane subunit. ASGP-1 and ASGP-2 is a multifunctional glycoprotein complex. ASGP-1, through its O-glycosylation of the tandem repeat domain, provides anti-recognition and anti-adhesive properties to tumor cells. This property is involved in reducing the killing of tumor cells by natural killer cells and it is also important in high metastatic capacity of tumor cells. ASGP-2 has two epidermal growth factor-like domains. ASGP-2 appears to be able to bind and modulate ErbB2 receptor phosphorylation, which allows rapid growth of tumor cells. Sialomucin complex (SMC, rat homologue of human MUC4) expression is found in normal secretory epithelial tissues in the adult rat, where the protein has multiple regulatory mechanisms (Carraway, K.L. et al 1999). SMC is found in normal virgin mammary gland, elevated in the lactating gland, and further amplified in rat mammary adenocarcinoma. Transforming growth factor-beta (TGF-ß) inhibits SMC expression. Abnormal expression of MUC4/SMC is found in several human epithelial tumors such as, breast, lung, cervix, and pancreas carcinomas. Unregulated MUC4 may promote tumor metastasis, which suggests that it has an important role in human tumor biology. For example, several studies indicate that the cytoplasmic tail of the transmembrane mucin is involved in cell-signalling events such as Sos-ras pathway, beta-catenin, and ErbB2 signalling pathway.
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats.
mol wt:239/595kDa
Other Aliases:xy-8328R PP4R3B丝氨酸/苏氨酸蛋白磷酸酶3B抗体
xy-9547R PGGT1A蛋白香叶烯基转移酶1α抗体
xy-4895R PIRH2泛素连接酶抗体
xy-9371R PGBD3PGBD3蛋白抗体
xy-8340R PANK4泛酸激酶4抗体
xy-6443R PMCA1细胞膜钙ATP酶1抗体
xy-6450R PMCA4细胞膜钙ATP酶4抗体
xy-8201R PMCA4B细胞膜钙ATP酶4B抗体
xy-6499R PMCA细胞膜钙转运ATP酶抗体
xy-4710R SLCO2A1溶质载体蛋白家族21成员2抗体
xy-7872R PPHLN1脉周蛋白1抗体（胃癌抗原蛋白Ga50）
xy-9594R PINX-1端粒酶抑制因子PinX-1抗体
xy-6445R PRLR泌乳素受体抗体
xy-11622R PKD1L3多囊肾蛋白1样3抗体
xy-11623R PIRT磷酸肌醇相互作用蛋白抗体
xy-11739R Nucleoside phosphorylase嘌呤核苷磷酸化酶抗体
xy-8608R phospho-PKC Epsilon(Ser729)磷酸化蛋白激酶C/p-PKC ε抗体
xy-12035R Paralemmin 1细胞膜调控蛋白Paralemmin 1抗体
xy-3686R PHD2脯氨酸羟化酶2抗体
xy-2241R PSAP鞘脂激活蛋白原抗体
xy-3674R PBR外周苯二氮受体抗体
xy-7722R APRIN雄激素诱导增殖抑制蛋白抗体
xy-11993R Phosphoserine磷酸化丝氨酸抗体
xy-7711R PCNT中心粒周蛋白抗体
xym-2006M PCNA(1C11)小鼠增殖细胞核抗原单克隆抗体
xy-5981R phospho-p107(Thr369) 磷酸化视网膜母细胞瘤样蛋白p107抗体
xy-9357R Proteasome 20S beta 3蛋白酶体PSMβ3抗体
xy-9358R Proteasome 20S beta 6蛋白酶体PSMβ6抗体
xy-9359R Proteasome 20S beta 7蛋白酶体PSMβ7抗体
xy-2567R PTP/PTPase/CD148蛋白酪氨酸磷酸酶CD148抗体
粘蛋白-4抗体
MUC4 (Mucin 4) is a high molecular weight transmembrane mucin that is overexpressed in many carcinomas and is a risk factor associated with a poor prognosis. MUC4 has been found to be a heterodimeric glycoprotein complex that consists of ASGP-1 (ascites sialoglycoprotein-1), an O-glycosylated mucin subunit, and ASGP-2, an N-glycosylated transmembrane subunit. ASGP-1 and ASGP-2 is a multifunctional glycoprotein complex. ASGP-1, through its O-glycosylation of the tandem repeat domain, provides anti-recognition and anti-adhesive properties to tumor cells. This property is involved in reducing the killing of tumor cells by natural killer cells and it is also important in high metastatic capacity of tumor cells. ASGP-2 has two epidermal growth factor-like domains. ASGP-2 appears to be able to bind and modulate ErbB2 receptor phosphorylation, which allows rapid growth of tumor cells. Sialomucin complex (SMC, rat homologue of human MUC4) expression is found in normal secretory epithelial tissues in the adult rat, where the protein has multiple regulatory mechanisms (Carraway, K.L. et al 1999). SMC is found in normal virgin mammary gland, elevated in the lactating gland, and further amplified in rat mammary adenocarcinoma. Transforming growth factor-beta (TGF-ß) inhibits SMC expression. Abnormal expression of MUC4/SMC is found in several human epithelial tumors such as, breast, lung, cervix, and pancreas carcinomas. Unregulated MUC4 may promote tumor metastasis, which suggests that it has an important role in human tumor biology. For example, several studies indicate that the cytoplasmic tail of the transmembrane mucin is involved in cell-signalling events such as Sos-ras pathway, beta-catenin, and ErbB2 signalling pathway.
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats.
mol wt:239/595kDa
Other Aliases:xy-8328R PP4R3B丝氨酸/苏氨酸蛋白磷酸酶3B抗体
xy-9547R PGGT1A蛋白香叶烯基转移酶1α抗体
xy-4895R PIRH2泛素连接酶抗体
xy-9371R PGBD3PGBD3蛋白抗体
xy-8340R PANK4泛酸激酶4抗体
xy-6443R PMCA1细胞膜钙ATP酶1抗体
xy-6450R PMCA4细胞膜钙ATP酶4抗体
xy-8201R PMCA4B细胞膜钙ATP酶4B抗体
xy-6499R PMCA细胞膜钙转运ATP酶抗体
xy-4710R SLCO2A1溶质载体蛋白家族21成员2抗体
xy-7872R PPHLN1脉周蛋白1抗体（胃癌抗原蛋白Ga50）
xy-9594R PINX-1端粒酶抑制因子PinX-1抗体
xy-6445R PRLR泌乳素受体抗体
xy-11622R PKD1L3多囊肾蛋白1样3抗体
xy-11623R PIRT磷酸肌醇相互作用蛋白抗体
xy-11739R Nucleoside phosphorylase嘌呤核苷磷酸化酶抗体
xy-8608R phospho-PKC Epsilon(Ser729)磷酸化蛋白激酶C/p-PKC ε抗体
xy-12035R Paralemmin 1细胞膜调控蛋白Paralemmin 1抗体
xy-3686R PHD2脯氨酸羟化酶2抗体
xy-2241R PSAP鞘脂激活蛋白原抗体
xy-3674R PBR外周苯二氮受体抗体
xy-7722R APRIN雄激素诱导增殖抑制蛋白抗体
xy-11993R Phosphoserine磷酸化丝氨酸抗体
xy-7711R PCNT中心粒周蛋白抗体
xym-2006M PCNA(1C11)小鼠增殖细胞核抗原单克隆抗体
xy-5981R phospho-p107(Thr369) 磷酸化视网膜母细胞瘤样蛋白p107抗体
xy-9357R Proteasome 20S beta 3蛋白酶体PSMβ3抗体
xy-9358R Proteasome 20S beta 6蛋白酶体PSMβ6抗体
xy-9359R Proteasome 20S beta 7蛋白酶体PSMβ7抗体
xy-2567R PTP/PTPase/CD148蛋白酪氨酸磷酸酶CD148抗体
粘蛋白-4抗体
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文献和实验相关实验
这是很早以来就被使用的一个名词，是把见于动物体中的其本身不清楚的粘性物质，有人直接称为粘蛋白。并指出除粘性高以外，加热后也不象蛋白质那样具有可以凝固的性质，也不象明胶那样能够凝胶化。根据现代化学知识表明，粘蛋白不是均一的物质，它是一组蛋白多糖（粘多糖蛋白质）或糖蛋白的混合物。可肯定地说，它是由蛋白质分出许多糖链，分支处是和丝氨酸或苏氨酸的羟基以糖苷键所形成的化合物组成的主体。所以现在在糖蛋白质中有的则把相当于上述结构的化合物特称为粘蛋白型糖蛋白。
抗体的结构决定了其对应的功能，同一抗体的V区和C区的氨基酸组成和顺序不同，决定了其功能上的差异。V区和C区的组成和结构，决定了抗体的生物学功能。 图1：抗体的主要功能（图片来源：Abbas et al: Cellular and Molecular Immunology, 7e.) 1、特异性识别功能 抗体可以通过其结构上的可变区域与抗原结合，同时，具有极高的特异性。这种特异性识别功能可以使抗体识别和结合到感染的病原体，肿瘤细胞等不同种类的分子，帮助免疫系统识别并定位到这些分子，进而启动
在动物的血液和粘性分泌物中虽然没有粘多糖，但存在着相当量（4%以上）的含己糖胺的蛋白成分，过去（ 1960年以前）对这些成分由于没有充分提纯，关于其结构也缺乏了解，所以为了方便就称为类粘蛋白，以和一类糖蛋白（狭义的糖蛋白含己糖胺 4%以下）相区别。进而也使用过所谓中性类粘蛋白（血液型物质、血浆类粘蛋白等）、酸性类粘蛋白（颚下腺粘蛋白、血清类粘蛋白、含唾液酸类粘蛋白等）、不溶性类粘蛋白（卵粘蛋白）等详细的分类名称。现在由于对分子结构的认识飞跃进步、根据这些来对组成进行分类和定使用名称其价值
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粘蛋白-4抗体
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