SPA 1是重要的Rap1GTP酶激活蛋白.SPA-1参与细胞的程序性死亡,在很多恶性肿瘤的发生、发展中起到一定的作用。 [FUNCTION] GTPase activator for the nuclear Ras-related regulatory protein Rap1, Rsr1 and Ran in vitro, converting it to the putatively inactive GDP-bound state. Affects cell cycle progression. [SUBCELLULAR LOCATION] Nucleus. Note=Mostly nuclear. [TISSUE SPECIFICITY] Preferentially expressed in both fetal and adult lymphohematopoietic tissues. [INDUCTION] By mitogens. [SIMILARITY] Contains 1 PDZ (DHR) domain. [SIMILARITY] Contains 1 Rap-GAP domain. [SEQUENCE CAUTION] Sequence=BAA01973.1; Type=Frameshift; Positions=Several