肝细胞生长因子激活物抑制因子抗体

肝细胞生长因子激活物抑制因子抗体产品类别

兔抗人、大、小鼠HAI-1蛋白抗体

产品价格

0.2ml/860元

产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

肝细胞生长因子激活物抑制因子抗体产品介绍

HAI-1 是一种含两个 Kunitz 域的跨膜蛋白，可抑制由细胞膜分泌的并且以游离形式存在的 HGFA 。 HAI-1 也可以作用于其它丝氨酸蛋白酶.
HAI-1 主要在胎盘、肾、胰腺、前列腺和小肠，也有报道称 HAI-1 会在肝癌中表达。
HGFA Inhibitor 1 is an endogenous inhibitor of the kunitz-type serine proteinase HGF-activator (HGFA). HGF was first described as a hepatocyte-specific mitogen and survival factor, and has since been shown to exert a variety of actions on many cell types by binding to its MET receptor. HGF is activated by cleavage of the single-chain form to form a two-chain version by HGFA. HGFA Inhibitor 1 also inhibits trypsin, and MTSP-1 (Matriptase), a serine proteinase that also activates HGF. HGFB Inhibitor 1 is a splice variant of HGFA Inhibitor 1, and contains a 16 amino acid insert after the first kringle domain, relative to the HGFA Inhibitor 1 sequence.
mol wt:58kDa
Other Aliases:
Hepatocyte Growth Factor Activator Inhibitor 1; Spint1; Hai1; HGFA Inhibitor 1; HAI-1