- ￥245 - 3080
- MedChemExpress(MCE)
- 美国
- HY-16346
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
CID 6451149
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
290297-26-6
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥662.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥245.0 |
| 规格： | 5 mg | 产品价格： | ￥520.0 |
| 规格： | 10 mg | 产品价格： | ￥630.0 |
| 规格： | 25 mg | 产品价格： | ￥1260.0 |
| 规格： | 50 mg | 产品价格： | ￥1920.0 |
| 规格： | 100 mg | 产品价格： | ￥3080.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Netupitant
CAS No. : 290297-26-6
MCE 国际站：Netupitant
产品活性：Netupitant (CID-6451149) 是高效、选择性、具有口服活性的 Neurokinin-1 受体 (NK1) 拮抗剂，在 CHO 细胞中对 hNK1 的 Ki 值为 0.95 nM。Netupitant 具有止吐作用。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：Neurokinin Receptor
In Vitro: Netupitant (CID-6451149) binds with high affinity the human NK1 receptor (pKi=9.0) with more than 1000 fold selectivity over the NK2 and NK3 (pKi=5.8 for both sites).
Netupitant (1, 10, 100 nM) concentration-dependently antagonizes the stimulatory effects of substance P (SP) showing insurmountable antagonism (pKB=8.87) in CHO NK1 cells.
In Vivo: Netupitant (CID-6451149; 1-10 mg/kg; ip) dose-dependently inhibits SP-elicited the typical scratching, biting and licking response in mice. In gerbils, foot tapping behavior evoked by the intracerebroventricular injection of a NK1 agonist is dose-dependently counteracted by Netupitant given intraperitoneally (ID50 1.5mg/kg) or orally (ID50 0.5mg/kg).
Netupitant (0.1-3 mg/kg; i.v.) produces a concentration-dependent inhibition (mean pKB=9.24) of the responses to SP-methylester (SP-OMe) in the detrusor muscle. Netupitant decreases the frequency of reflex bladder contractions.
相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | Endocrinology Compound Library | Orally Active Compound Library | Neurotransmitter Receptor Compound Library | FDA Approved & Pharmacopeial Drug Library | Children’s Drug Library | EMA-Approved Drug Library | Human Metabolite Library | Off-patent Drug Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Substance P | Aprepitant | Senktide | Fezolinetant | Fosaprepitant dimeglumine | SB-222200 | Rolapitant | Talnetant | L-732138 | Saredutant | Maropitant | Casopitant mesylate | Neurokinin A TFA | H-Glu(OtBu)-OtBu hydrochloride | Pavinetant | Vofopitant dihydrochloride | Elinzanetant | Osanetant | Neurokinin B TFA | Vapreotide | Neurokinin A(4-10) TFA | Hemokinin 1 (mouse) | Men 10376 TFA | NKP608 | Spantide I | Substance P(1-7) TFA | Orvepitant maleate | Fosnetupitant
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
