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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
ICL 670
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
201530-41-8
- 规格：
10 mM * 1 mL/2 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥632.0 |
|---|---|---|---|
| 规格： | 2 mg | 产品价格： | ￥450.0 |
| 规格： | 5 mg | 产品价格： | ￥770.0 |
| 规格： | 10 mg | 产品价格： | ￥1350.0 |
| 规格： | 25 mg | 产品价格： | ￥2430.0 |
| 规格： | 50 mg | 产品价格： | ￥3645.0 |
| 规格： | 100 mg | 产品价格： | ￥5468.0 |
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Deferasirox
CAS No. : 201530-41-8
MCE 国际站：Deferasirox
产品活性：Deferasirox (ICL 670) 是具有口活性的，可用于铁离子过量的螯合剂。
研究领域：Anti-infection | Apoptosis
作用靶点：Bacterial | Ferroptosis
In Vitro: In LX-2 cells treated with 50 μM deferasirox for 12 h, α1(I)procollagen expression is decreased by 25%, with maximal reductions (10-fold) seen following 24-120 h of treatment. Similarly, α-smooth muscle actin (αSMA) expression is significantly lower. Deferasirox had anti-proliferative effects on HL-60 or KG-1 myeloid leukemia cell lines at a concentration as low as 5 μM . The cytotoxicity is both dose and time dependent. The viability of both EL4 cells and L1210 cells incubated with deferasirox decrease in a concentration-dependent manner.
In Vivo: The tumor is significantly smaller in the SIO mice treated with deferasirox compared with control. Mice treated with DFX showed longer survival than the other groups. Deferasirox has a survival benefit for SIO leukemia murine model in terms of iron chelation and antileukemic therapy.
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