Danegaptide

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Danegaptide

CAS No. : 943134-39-2

MCE 国际站：Danegaptide

产品活性：Danegaptide (GAP-134) 是一种有效的，选择性的，具有口服活性的 gap-junction 修饰剂，具有抗心律不齐的作用。

研究领域：Cytoskeleton

作用靶点：Gap Junction Protein

In Vitro: Danegaptide (GAP-134, compound 9f; 0.01 nM-100 μM) dose dependently reduces dye uptake in cultured C6 glioma cells in a manner.

In Vivo: Danegaptide (GAP-134, compound 9f) is evaluated for in vivo efficacy in the mouse CaCl₂ model after oral administration. For doses of 5-20 mg/kg po, Danegaptide significantly prolongs the time to conduction block in mice after the infusion of CaCl₂.
Danegaptide (GAP-134) is biologically active upon oral administration at an average plasma concentration of 250 nM, and reduces atrial fibrillation in a dog model. Danegaptide has no effect on heart rate, arterial blood pressure or other electrocardiogram (ECG) parameters. Danegaptide is an effective antiarrhythmic compound in the setting of ischaemia/reperfusion-induced arrhythmogenesis in barbiturate-anesthetized, open-chest beagles.

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