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文献和实验Gene Targeting in Drosophila and Caenorhabditis elegans With Zinc-Finger Nucleases
Zinc-finger nucleases (ZFNs) are promising new tools for enhancing the efficiency of gene targeting in many organisms. Because of the flexibility of zinc finger DNA recognition, ZFNs can be designed to bind many different genomic sequences
Gene Editing in One‐Cell Embryos by Zinc‐Finger and TAL Nucleases
immunoglobulin gene disruption and targeted replacement in rabbit using zinc finger nucleases. PLoS One 6:e21045. Gallagher, S. R. 2011. Quantitation of DNA and RNA with absorption
Using Nucleases to Stimulate Homologous Recombination
at a unique site, which makes possible detailed analysis of the repair products. In addition, targeted mutagenesis and gene replacement are stimulated in the immediate vicinity of the break site. To utilize meganucleases with long recognition sequences
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