Polycomb & Trithorax 靶基因 ChIP

Human Polycomb & Trithorax Target Genes ChIP PCR Array Product Species Technology Cat. No. Polycomb & Trithorax Target Genes EpiTect ChIP qPCR Array Human Histone Modifications GH-505A Polycomb & Trithorax Target Genes EpiTect ChIP qPCR Array Mouse Histone Modifications GM-505A
The Human Polycomb & Trithorax Target Genes EpiTect Chip qPCR Array profiles the histone modifications or “histone code” of 84 genes targeted by the Polycomb and Trithorax complexes of chromatin modification enzymes and remodeling factors. Histone modifications regulate chromatin structure, gene activity and cellular identity. The polycomb and trithorax complexes maintain epigenetic control of cell type specific gene expression patterns important for cellular identity via histone modification. The polycomb complex causes transcriptional repression, while the trithorax complex reverses that effect to maintain an active state of transcription. Polycomb complex activity controls the proper differentiation of induced and embryonic pluripotent stem cells, as confirmed via identified target genes and reflected in the content of this array. Dysregulation of polycomb complex activity promotes oncogenesis by causing inappropriate expression of cell identity and differentiation genes, making polycomb target genes and their histone code also important to cancer research. Using chromatin immunoprecipitation and this real-time PCR Array, you can easily and reliably analyze the histone modification patterns associated with a focused panel of polycomb and trithorax target genes.

Cellular Mechanisms:
Differentiation: BMP2, CADM1 (TSLC1), CCND2, CHST11, DHH, DKK1, EFNB1, EPHA4, EPHB3, FOXA2 (HNF3B), GATA2, GATA6, HAND1, HES1, IL6R, IRX3, JUN, KLF4, OTX2, PDGFRA, PMP22, RARB, SALL1, SOX17, THPO, TRIM10, TRIM15, UCP1, WNT5A.
Signal Transduction: BMP2, CDC42EP1, CDKN1A (p21CIP1/WAF1), CHST11, CXCL16, CXCR7, DKK1, DKK2, EPHA4, EPHB3, GAS6, HES1, HEY1, IGFBP1, IL6R, IRS4, JUN, OTX2, PDGFRA, PRKCH, PRKG2, PTPRA, RARB, RASD1, RASSF1, SMOC2, SOX17, TACSTD2, TCF7, TNFRSF19, WNT5A.
Cell Cycle: BMP2, CCND2, CDKN1A (p21CIP1/WAF1), DHH, ESX1, G0S2, JUN, RASSF1.
Apoptosis: CADM1 (TSLC1), CDKN1A (p21CIP1/WAF1), CHST11, GATA6, IL6R, JUN, RARB, RYBP, SERPINB2 (PAI-2), TNFRSF19.
Extracellular Matrix Organization: CTSA, LOX, PDGFRA, TIMP3.
Chromatin Modification: BMI1 (PCGF4), CBX8, HMGN2, RBBP7.
Other: CDH11, CYP1B1, DGAT2, FAM65A, HS3ST1, HS6ST2, MGLL, MYO5B, NID2, NPTX1, THBD, TMEM66, USP3, VSNL1.
Cellular Functions:
Transcription Factors: ATF3, ESX1, FOXA2 (HNF3B), GATA2, GATA3, GATA4, GATA6, HAND1, HEY1, HOXA10, HOXA5, IRX3, JUN, KLF4, MEIS2, OTX2, RARB, SALL1, SATB1, TRIM15, TSHZ1.
Transporters: KCNA1, SLC30A4, SLC34A2, TRPM3, UCP1.