Polycomb & Trithorax复合物DNA甲基化P
CR芯片 Polycomb & Trithorax Complexes DNA Methylation PCR Array- 询价
- Polycomb & Trithorax Complexes DNA Methylation PCR Array
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- 2026年01月21日
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Polycomb & Trithorax Complexes DNA Methylation PCR Array
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| Human Polycomb & Trithorax Complexes DNA Methylation PCR Array, Signature Panel: EAHS-571Z |
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| The Human Polycomb & Trithorax Complexes EpiTect Methyl II Signature PCR Array profiles the methylation status of 22 gene promoters involved in expression silencing during development and oncogenesis. Polycomb Group (PcG) protein complex epigenetic machinery remodels chromatin structure preventing gene expression, particularly of homeobox (HOX) genes, and this remodeling is typically only reversed by germline differentiation. However, the severity and invasiveness of several cancer types also correlate with aberrant PcG gene over-expression. Profiling cell or tissue samples with these arrays may help correlate CpG island methylation status with biological phenotypes. The results may also provide insights into the molecular mechanisms and biological pathways behind differentiation and development or oncogenesis. With a simple restriction enzyme digestion and real-time PCR, research studies can analyze the methylation status of 22 different Polycomb Group genes with this DNA methylation PCR array. Both 96-well and 384-well ( 4 X 96 ) formats are available. The EpiTect Methyl II PCR Arrays use the MethylScreen™ Technology provided under license from Orion Genomics, LLC.
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Polycomb Cofactors: ASXL1, ASXL2, CBX2, CBX4, CTBP2, EPC1, EPC2, PCGF3, PCGF6, PHF19, TRIM27.
Trithorax Cofactor: BRPF1.
Other Epigenetic Regulators: BRPF3.
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文献和实验浅析染色质免疫沉淀（ChIP）技术在 DNA 与蛋白质相互作用研究中的重要性
-19]； xChIP：用来研究DNA及低结合力蛋白，采用甲醛或紫外线进行 DNA 和蛋白交联，超声波片段化染色质，然后进行片段富集及后续分析，适用于多数非组蛋白的蛋白，例如 [9, 15, 20]。 X-ChIP 试验的一般过程 以上两种方法在分离 DNA-蛋白质复合物之后，对 DNA 进行 PCR 扩增，验证目标序列的存在。除验证实验外，ChIP DNA也可以进行测序分析，这种方法被称为 ChIP-seq [22] ；也可做芯片分析，这种方法被称为 ChIP on CHIP 或 ChIP
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