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黑色素瘤DNA甲基化PCR芯片Melanoma DNA Me

thylation PCR Array
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  • ¥4800
  • Melanoma DNA Methylation PCR Array
  • 上海
  • 2026年01月29日
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    上海英拜生物科技有限公司
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    • 文献和实验
    • 技术资料
    • 服务名称：

      Melanoma DNA Methylation PCR Array

    • 提供商：

      SAB

    Human Melanoma DNA Methylation PCR Array, Signature Panel: EAHS-081Z
    The Human Melanoma EpiTect Methyl II Signature PCR Array profiles the promoter methylation status of a panel of 22 genes showing hypo- or hypermethylation in melanoma. Melanoma accounts for less than 5% of skin cancers, but 80% of the deaths, illustrating the aggressiveness and malignancy of the disease. Epigenetic studies of dysregulated and hypermethylated tumor suppressor genes have identified novel therapeutic targets for melanoma. This array includes genes frequently observed by genomewide analyses to be hypermethylated in melanoma, as well as genes involved in melanoma onset and progression. Profiling cellular or fresh tissue genomic DNA samples with these arrays may help correlate CpG island methylation status with biological phenotypes. The results may also help provide further insights into the molecular mechanisms and biological pathways behind oncogenesis and cancer biology. With a simple restriction enzyme digestion and real-time PCR, research studies can analyze the promoter methylation status of 22 different genes involved in melanoma initiation and progression with this DNA methylation PCR array.
    The EpiTect Methyl II PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
    The EpiTect Methyl II PCR Arrays use the MethylScreen™ Technology provided under license from Orion Genomics, LLC
    Signaling Pathways Dysregulated in Melanoma: GDF15 (PLAB), RB1.
    Cellular Stress Responses:
    Drug & Chemical Response: CDH3, DNAJC15, LRP2, SOCS3.
    Immune: DPP4, IRF8, PRDX2, THBD.
    Hypoxia: AKAP12, DPP4, SOCS3.
    Oxidative: PRDX2, TPM1.
    Cell Growth & Proliferation: AKAP12, DPP4, LRP2, PPP2R4, PRDX2, RB1, SOCS2.
    Extracellular Matrix & Cell Adhesion: ADAMTS18, CDH3, DPP4, ENC1, MME, QPCT, SOCS2, SOCS3, TPM1.
    Apoptosis Regulation: PRDX2, SOCS2, SOCS3, TNFRSF10A, TP53INP1.
    Transcription Factors & Cofactors: IRF8, RB1, TNFRSF10A.
    Others: PPP1R3C, RASEF

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    相关实验

    • review of DNA methylation

      清楚。除上述复合物外，MBD还与几种与转录抑制有关的蛋白有一定关系，如c-ski,N-CoR。二、DNA甲基化与肿瘤形成（一）、CPG岛的高度甲基化肿瘤细胞呈现两种绝然相反的甲基化模式：即整体基因组甲基化不足和CPG岛超甲基化。这两种甲基化模式在肿瘤形成中均起重要作用。现对CPG岛内甲基化的研究比较透彻，其在肿瘤形成中的作用也更加明确。1、候补基因(candidante gene)的分析1986年首先报道[1]人类肿瘤CPG岛超甲基化，直到1996年[2],基于PCR的甲基化技术的出现，对CPG岛甲基

    • Methylation Profiling Using Methylated DNA Immunoprecipitation and Tiling Array Hybridization

      DNA methylation is an important epigenetic modification that regulates development and plays a role in the pathophysiology of many diseases. It is dynamically changed during germline development. Methylated DNA immunoprecipitation (MeDIP

    • DNA methylation

      of techniques have been developed. Most early studies used methylation sensitive restriction enzymes to digest DNA followed by Southern detection or PCR amplification. Recently, bisulfite reaction based methods have become very popular such as methylation

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