神经发育与疾病 miRNA PCR芯片 Neurologic

Human Neurological Development & Disease miRNA PCR Array: MIHS-107Z 神经发育与疾病 miRNA PCR芯片
The Human Neurological Development & Disease miScript miRNA PCR Array profiles the expression of 84 miRNAs differentially expressed during neuronal development or the progression of neurological diseases. This array provides neuroscience researchers with a convenient way to analyze the miRNAs most relevant to normal nervous system development and/or psychiatric and neurodegenerative disorder progression. Certain miRNAs, such as miR-9, promote neurodevelopment processes such as neurogenesis and synaptic plasticity. Microarray analyses of diseased brain tissues show a variety of significantly dysregulated miRNAs. However, few of these analyses have yet to focus on individual miRNA function and mechanism of action during specific disease processes. The profiling results from this array can serve as a useful marker for neuronal differentiation processes and may yield insights into the molecular mechanisms behind the pathogenesis of neurological disorders. The results can also help enhance basic neurological research since dysregulated developmental processes can lead to neurological diseases, and both often involve similar miRNA-regulated biological pathways. A set of controls present on this array enables data analysis using the ΔΔCT method of relative quantification, assessment of reverse transcription performance, and assessment of PCR performance. Using SYBR Green-based real-time PCR, the expression of a focused panel of miRNAs related to neurological research can be easily and reliably analyzed with this miScript miRNA PCR Array. miScript miRNA PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention or treatment of a disease. 96-well, 384-well ( 4 x 96 ), and Rotor-Disc 100 formats are available.

Development: miR-124-3p, miR-125b-5p, miR-132-3p, miR-134, miR-138-5p, miR-9-5p.
Autistic Disorders: miR-106b-5p, miR-128, miR-132-3p, miR-140-5p, miR-146b-5p, miR-148b-3p, miR-15a-5p, miR-15b-5p, miR-181d, miR-193b-3p, miR-212-3p, miR-27a-3p, miR-320a, miR-381-3p, miR-431-5p, miR-432-5p, miR-484, miR-539-5p, miR-652-3p, miR-7-5p, miR-93-5p, miR-95.
Schizophrenia: let-7d-5p, let-7e-5p, miR-105-5p, miR-106b-5p, miR-107, miR-126-5p, miR-128, miR-130a-3p, miR-138-5p, miR-152, miR-15a-5p, miR-15b-5p, miR-181a-5p, miR-195-5p, miR-20a-5p, miR-212-3p, miR-24-3p, miR-26b-5p, miR-27a-3p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-302a-5p, miR-302b-5p, miR-30d-5p, miR-338-3p, miR-346, miR-381-3p, miR-409-3p, miR-455-5p, miR-484, miR-485-5p, miR-487a, miR-489, miR-499a-5p, miR-512-3p, miR-518b, miR-7-5p, miR-9-3p, miR-92a-3p.
Anxiety Disorder: miR-128, miR-485-3p, miR-509-3p.
Tourette's Syndrome: miR-24-3p.
Alzheimer's Disease: let-7b-5p, let-7c, let-7d-5p, let-7e-5p, let-7i-5p, miR-101-3p, miR-106b-5p, miR-107, miR-128, miR-139-5p, miR-146a-5p, miR-15a-5p, miR-15b-5p, miR-151a-3p, miR-181a-5p, miR-19b-3p, miR-20a-5p, miR-22-3p, miR-24-3p, miR-26b-5p, miR-27a-3p, miR-28-5p, miR-298, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-30d-5p, miR-320a, miR-328, miR-346, miR-34a-5p, miR-376b-3p, miR-433, miR-485-5p, miR-488-3p, miR-511, miR-9-5p, miR-92a-3p, miR-93-5p, miR-98-5p.
Prion Diseases: let-7b-5p, miR-128, miR-139-5p, miR-146a-5p, miR-191-5p, miR-203a, miR-320a, miR-337-3p, miR-338-3p, miR-339-5p, miR-342-3p.
Huntington's Disease: miR-124-3p, miR-132-3p, miR-135b-5p, miR-29a-3p, miR-29b-3p, miR-9-5p, miR-9-3p.
Parkinson's Disease: miR-133b, miR-433, miR-7-5p.
Spinocerebellar Ataxia 1: miR-101-3p, miR-130a-3p, miR-19b-3p